Anomalia reportada em fase aguda na malária será tema de palestra no ILMD

Dentre as anomalias reportadas em fase aguda na malária, a trombocitopenia é uma manifestação hematológica muito comum, no entanto, a ocorrência de sangramento é um evento raro nos pacientes. A patogênese da trombocitopenia malária é multifatorial e envolve destruição e consumo de plaquetas.

O tema trombocitopenia será abordado durante palestra oferecida pelo Centro de Estudos do Instituto Leônidas & Maria Deane (ILMD/ Fiocruz Amazônia), na próxima sexta-feira (24/02), às 9h, no Salão Canoas, auditório da Instituição. A apresentação será ministrada pelo Dr. Paulo Nogueira, pesquisador do ILMD.

Segundo o pesquisador, “alguns mecanismos fisiopatológicos já foram demonstrados recentemente: a coagulopatia e adesão/destruição endotelial; a destruição por fagocitose associada com elevação dos níveis séricos de citocinas inflamatórias; e a elevação dos níveis de marcadores de estresse oxidativo como causa de danos estruturais e funcionais nas plaquetas”, explicou.

Especula-se que distúrbios de esplenomegalia e alterações da medula óssea estejam associados a trombocitopenia, e citocinas pró e anti-inflamatórias podem funcionar como marcadores sorológicos da trombocitopenia na malária. A palestra vai abordar aspectos atuais desta fisiopatologia

SOBRE O PALESTRANTE

Paulo é graduado em Ciências Biológicas pela Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), mestre em Biologia Funcional e Molecular pela Universidade Estadual de Campinas (Unicamp), doutor em Relação Patógeno Hospedeiro pelo Instituto de Ciências Biomédicas da Universidade de São Paulo (USP), e pós doutor em biologia da relação patógeno hospedeiro pela Universidade do Mediterrâneo, Marselha (França).

Atua na área de Imunologia, com ênfase em receptores celulares, anticorpos, biologia molecular e clonagem gênica para expressão de antígenos recombinantes. É coordenador do Programa de Pós-Graduação Stricto Sensu em Biologia da Interação Patógeno Hospedeiro (PPGBIO-Interação), e vice-líder do Laboratório de Diagnóstico e Controle de Doenças Infecciosas na Amazônia (DCDIA), do ILMD/Fiocruz Amazônia.

ILMD/Fiocruz Amazônia, Por Eduardo Gomes.

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