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The purpose of this retrospective time-lapse data analysis from transferred preimplantation human embryos was to identify early morphokinetic cleavage variables that are related to implantation and live birth following in vitro fertilization IVF. All embryos were monitored from fertilization check until embryo transfer for a minimum of 44 hours.
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The study was designed to assess the association between day 2 embryo morphokinetic variables with implantation and live birth based on Known Implantation Data KID. The kinetic variables were subjected to quartile-based analysis.
The predictive ability for implantation and live birth was studied using receiver operator characteristic ROC curves. Three morphokinetic variables, time to Agreemetn t2duration of second cell cycle cc2 below one threshold and cc2 above another threshold had the highest predictive value with regards to implantation and live birth following IVF treatment. The predictive pre-transfer information has little divergence between fetal heartbeat and live birth data and therefore, at least for early morphokinetic variables up to the four-cell stage t4conclusions and models based on fetal heartbeat data can be expected to be valid for live birth datasets as well.
The three above mentioned variables t2, cc2 below one threshold and cc2 above another threshold may supplement morphological evaluation in embryo selection and thereby improve Agremeent outcome of in vitro fertilization treatments. This is an open access article distributed under the terms of the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Data Availability: The underlying data set analyzed during this current study is not freely available due to national regulations. Publishing data that might aid even peripherally in e. Therefore, data are not publicly available source they contain information that could compromise the privacy of research participants.
The data that support the findings of this study are available on request from Klinikk Hausken and the contact person is Dr. Torolf Holst-Larsen.
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Hereby, an anonymized data set may be made available under compliance with GDPR. Contact details: Dr. Competing interests: Co-author B.]
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