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The cellular mechanism s linking macrophages to norepinephrine NE -mediated regulation of thermogenesis have been a topic of debate.
NE uptake by SAMs is prevented by genetic deletion of Slc6a2 or inhibition of the encoded transporter. Genetic ablation article source Slc6a2 Obesity The Obesity Contributor SAMs increases brown adipose tissue BAT content, causes browning of white fat, increases thermogenesis, and leads to substantial and sustained weight loss in obese mice. Obessity further show that this pathway is conserved, as human sympathetic ganglia also contain SAMs expressing the analogous molecular machinery for NE clearance, which thus constitutes a potential target for obesity treatment. Abstract The cellular mechanism s linking macrophages to norepinephrine NE -mediated regulation of thermogenesis have been a topic of debate.]
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