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Only 3 cases of coronavirus disease COVID were identified in Italy in the first half of February and all involved people who had recently traveled to China.

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Within 14 days, many other cases of COVID in the surrounding area were diagnosed, including a substantial number of critically ill patients. Since then, the number of cases identified in Italy has rapidly increased, mainly article source northern Italy, but all regions of the country have reported having patients with COVID The demographic characteristics of the Italian population differ from other countries.

The Table shows the age-specific fatality rate in Italy compared with that of China. The overall case-fatality rate in Italy 7. When data were stratified by age group, the case-fatality rate in Italy and China appear very similar for age groups 0 to 69 years, but rates are higher in Italy among individuals aged 70 years Cojpany older, and in particular Case Study Mars International Company those aged 80 years or older. This difference is difficult to explain.

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The distribution of cases is very different in the 2 countries: individuals aged 70 years or older represent Thus, the overall older age distribution in Italy relative to that in China may explain, in part, the higher average case-fatality rate in Italy. This method was selected because clear criteria for the definition of COVID—related deaths is not available. Electing to define death from COVID in this way may have resulted in an overestimation of the case-fatality rate.

Among these patients, the mean age was The mean number of preexisting diseases was 2. Overall, only 3 patients 0. The presence of these comorbidities might have increased the risk of mortality independent of Case Study Mars International Company infection. COVID—related deaths are not clearly defined in the international reports available so far, and differences in definitions of what is or is not a COVID—related death might explain variation in case-fatality rates among Group Adidas countries.

To better understand the actual causes of death, the ISS is now reviewing the complete medical records of all patients with positive RT-PCR results who have died in Italy.

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After an initial, extensive testing strategy of both symptomatic and asymptomatic contacts of infected patients in a very early phase of the epidemic, on February 25, the Italian Ministry of Health issued more stringent testing policies. This recommendation prioritized testing for patients with more severe clinical symptoms Case Study Mars International Company were suspected of having COVID and required hospitalization. Testing was limited for asymptomatic people or those who had limited, mild symptoms. This testing strategy resulted in a high proportion of positive results, ie, These more mild cases, with low fatality rate, were thus no longer counted in the denominator. Other countries have different testing strategies.

This may have led to the identification of a large number of individuals who had mild or limited symptoms, but a much lower case-fatality rate compared with Italy 1. In conclusion, the current data illustrate that Italy has a high proportion of older patients with confirmed COVID infection and that the older population in Italy may partly explain differences in cases and case-fatality rates among countries.

In addition, some patients who are currently infected may die in the near future, which may change the mortality pattern. From a research perspective, the comparisons discussed highlight the need for transparency in reporting testing policies, with clear reporting of the denominators used to calculate case-fatality rates and the age, sex, and clinical comorbid status of affected persons when comparing COVID case and mortality rates between Case Study Mars International Company countries and regions.

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Finally, because the outbreak is new, continued surveillance, with transparent and accurate reporting of patient characteristics and testing policies, is needed from multiple countries to better understand the global epidemiology of COVID Published Online: March 23, Correction: This article was corrected on April 16,to correct a data Case Study Mars International Company reported in the eighth paragraph number of women in the subsample was Conflict of Interest Disclosures: None reported. Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, article source, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

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