1.2 History of Malaria
An endoparasitic protozoan that causes malaria, Plasmodium, requires two hosts to complete its life cycle in; usually a mosquito and a vertebrate. Female Anopheles mosquito is responsible in the Essay On Malaria of malaria in human beings.
Human malaria is caused by four identified species of Plasmodia, namely Plasmodium Mzlaria, Plasmodium vivax, Plasmodium malariae and Plasmodium ovale. Recently, in addition to these four species, the simian parasite Plasmodium knowlesi have been identified to infect humans in Malaysia Cox-Singh, Singh, Malarria can be treated in just 48 hours; however the delay in diagnosis and treatment can cause fatal complications. Malaria caused by P. A dormant stage in the life cycle of P. The malaria due to P. The systematic position of malaria parasite described by Mhelhorn H. Italians used this word to refer the cause of Essay On Malaria fevers associated with exposure to marsh air or miasma.
In the first century A. Later, about 30 A. He concurred with the views expressed by Varro. InItalian physician Giovanni Maria Lancisifirst demonstrated a characteristic black pigmentation of the brain and spleen in the victims of malaria. InGiovanni Rasori of Parma suggested microorganism as Esswy cause for the disease. Later, ina German physician, Heinrich Meckel, identified round, spindle-shaped or ovoid structures containing black pigment granules in protoplasmic masses in the microscopic slides of blood from a patient with fever and observed similar entities in the spleen of an insane person during the autopsy. In Schutz observed these pigments in the internal organs of patient who had died of malaria.
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Soon afterwards, Virchow observed these pigmented bodies in the blood of a patient who had died from chronic malaria and specifically Essay On Malaria it with malaria. Finally, Charles Louis Alphonse Laveran in named a living organism as Oscillaria malariae and suggests it as the malaria parasite. In Camillo Golgi, established that there were at least two forms of the disease, one with tertian periodicity fever every other day and one with quartan periodicity fever every third day. He demonstrated that Essay On Malaria rupture of shizoints and release of merozoites into the blood stream coincided with the fever and correlated the severity of symptoms with parasite load in the blood.
InNobel Prize was awarded in Medicine for his discoveries in neurophysiology. Inthe sexual cycle of malaria parasite was demonstrated by Dr. In the same year, Ronald Ross demonstrated the presence of oocysts in the midgut of female anopheline mosquito click soon afterwards, he demonstrated the sporozoites infection in salivary glands of the mosquito and also carried out transmission of malaria in birds with an infected mosquito.
He was awarded the Nobel Prize in for establishing the fact that infected mosquitoes are responsible for transmission of malaria. InCharles Louis Essay On Malaria Laveran, Esszy awarded the Nobel Prize for Medicine and Physiology for his discovery of the malarial parasite and other significant contribution to parasitology.
In William Trager cultured P. Ina Colombian biochemist named Dr. Manuel Elkin Patarroyo developed the first synthetic Spf66 vaccine for P. Inthe genome of parasite Plasmodium falciparum and the vector Anopheles gambiae were successfully sequenced. Malaria is one of the oldest infectious diseases known to mankind.]
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