Hplc Determination Of Caffeine On Analgesic Powders - amazonia.fiocruz.br

Hplc Determination Of Caffeine On Analgesic Powders Video

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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. This study is based on the QbD development of extended-release ER extruded-spheronized pellets of Meclizine HCl and its comparative pharmacokinetic evaluation with immediate-release IR pellets. HPLC-fluorescence method was developed and validated for plasma drug analysis. The C max of IR pellets No significant food effect was observed on key pharmacokinetic parameters of ER pellets.

Meclizine HCl, prescribed for both prophylactic and therapeutic management of nausea, dizziness, and vomiting owing to motion sickness, acts as an antagonist on histamine H1 receptors. It is also used for the treatment of pruritus, Type 1 hypersensitivity reactions as well as vertigo related to disease conditions affecting the vestibular system.

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Meclizine HCl belongs to the biopharmaceutics classification system BCS class II, attributed to low solubility and high permeability 1. It is currently not available as an extended-release ER dosage form. In this study Quality by Design QbD based Eudragit coated ER Meclizine HCl extruded-spheronized pellet https://amazonia.fiocruz.br/scdp/essay/mormon-bank-utah/the-pros-and-cons-of-fundamentalism.php were designed along with immediate-release IR core pellets to improve patient compliance whilst reducing the intervals between doses and the risk of dose-dependent adverse and side effects. Both polymers are recommended for sustained release formulations. They are water-insoluble and provide pH-independent swelling. RL shows higher permeability compared to RS 5. No HPLC method along with fluorescence detection technique is previously reported for the determination of Meclizine in human plasma.

Imai et al. Arayne et al.

Mismatched matrix supernatant collected after plasma protein precipitation with acetonitrile, ACN was used for the preparation of p lasma calibration standards which does not match with the actual bio samples obtained from pharmacokinetic PK study 9. Sher et al. Liquid chromatography—mass spectrometry LC—MS based bioanalytical methods were costly. In line with extant literature, a sensitive and cost-effective alternate for quantification in human plasma by utilizing native luminescence of Meclizine was developed and validated as per FDA and Caaffeine guidelines for precision, selectivity, accuracy, robustness, recovery and stability 15 The effect of food on pharmacokinetic parameters of ER pellets was also investigated.

All solvents and reagents used were of analytical grade.

Freshly prepared distilled water DW was used and all analytical grade reagents and solvents were utilized. The wet massing of mixed powder was continued until cohesive and homogenous mass was achieved.]