Huntington s Disease Hd Is A Neurodegenerative - amazonia.fiocruz.br

Huntington s Disease Hd Is A Neurodegenerative - due

Symptoms of the disease usually start to develop around middle age. This disease affects significantly more Western Europeans than Asians or Africans and affects males and females equally. Since the disease often begins during middle age, people can go on to have children before they are aware they have the disease or that their offspring would be at risk. The HTT gene is located on chromosome 4 and codes for the huntingtin protein Htt. The mutated gene codes gives rise to a mutated Htt mHtt protein that gradually damages brain cells. As expanded copies of HTT are passed on through generations, the number of repeats can increase in successive generations causing a more severe disease to occur at an earlier age of onset than in previous generations. This is referred to as genetic anticipation. Huntington s Disease Hd Is A Neurodegenerative

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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Table S 2. Study population demographics. Table S 3. Prespecified comorbidities stratified by age group: HD cases versus PD controls analysis period only. Only the highest 10 odds ratios are presented for each age group. Table S 4.

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Prespecified comorbidities stratified by age group: HD cases versus GP controls analysis period only. Table S 5.

Prespecified comorbidities stratified by age group: HD cases versus PD controls analysis period and prior. Table S 6. Prespecified comorbidities stratified by age group: HD cases versus GP here analysis period and prior.

Table S 7. Overall comorbidities stratified by age group: HD cases versus PD controls analysis period only.

Table S 8. Overall comorbidities stratified by age group: HD cases versus GP controls analysis period only.

Only the highest ten odds ratios are presented for each age group. Table S 9.

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Overall comorbidities stratified by age group: HD cases versus PD controls analysis period and prior. Table Hdd Overall comorbidities stratified by age group: HD cases versus GP controls analysis period and prior. CI: confidence interval; OR: odds ratio. The condition gradually results in increasing disability, loss of independence, and ultimately death. Cases and controls were matchedand comorbidities were analyzed in each group during A total of matched individuals were assessed in each cohort. The use of antidepressant Cognitive disturbances in HD are characterized by a reduction in the speed and flexibility of mental processing, as well as decreased attention, visuospatial function, and emotional recognition.]