The Effect Of Cd44 Expression On Drug - amazonia.fiocruz.br

The Effect Of Cd44 Expression On Drug Video

Drug Abuse, Causes, Signs and Symptoms, Diagnosis and Treatment.

The Effect Of Cd44 Expression On Drug - think, that

Proliferative diabetic retinopathy PDR involves persistent, uncontrolled formation of premature blood vessels with reduced number of pericytes. Our previous work showed that advanced glycation endproducts AGEs induced angiogenesis in human umbilical vein endothelial cells, mouse retina, and aortic ring, which was associated with moesin phosphorylation. Here we investigated whether moesin phosphorylation may contribute to pericyte detachment and the development of PDR. Effects on moesin phosphorylation were examined using western blotting. Colocalization and interaction between CD44, phospho-moesin, and F-actin were observed. Experiments with cultured primary RMPs showed that AGE-BSA inhibited the proliferation, enhanced the migration, and increased moesin phosphorylation in a dose- and time-dependent manner. These effects were abrogated in cells expressing the non-phosphorylatable moesin mutant and the application of ROCK inhibitor Y attenuated AGE-induced alteration in cultured RMPs by abolishing the phosphorylation of moesin.

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Broad Institute believes that progress in biomedical research requires a fully inclusive community across sex, race, ethnicity, sexual orientation, age, and gender identity. Broad Institute is committed to making the extensive data, methods, and technologies it generates rapidly and readily accessible to the scientific community to drive biomedical progress around the world. Broad Institute works to build and sustain international consortia to speed discovery in areas including psychiatric research, infectious disease, cardiovascular disease, and cancer. Broad Institute fosters an environment in which scientists can take risks on bold ideas with transformative potential. Broad Institute is committed to addressing medical challenges across the world, including collaborating with scientists and public health experts to address important needs in developing countries. Broad Institute is a mission-driven community that brings together researchers in medicine, biology, chemistry, computation, engineering, and mathematics from across MIT, Harvard, and Harvard-affiliated hospitals, along with collaborators around the world. Broad Institute of MIT and Harvard is empowering a revolution in biomedicine to accelerate the pace at which the world conquers disease. The Effect Of Cd44 Expression On Drug.

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