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October 26, People with cancer who exercise generally have a better prognosis than inactive patients. Now, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth in mice: Physical activity changes the metabolism of the immune system's cytotoxic T cells and thereby improves their ability to attack Egyptian Mummification Ancient cells. The study is published in the journal eLife. Prior research has shown that physical activity can prevent unhealth as well as improve the prognosis of several diseases including various forms of cancer. Exactly how exercise exerts its protective effects against cancer is, however, still unknown, especially when it comes to the biological mechanisms.
One plausible explanation is A Study On The System physical activity activates the immune system and thereby bolsters the body's ability to prevent and inhibit cancer growth. In this study, researchers at Karolinska Institutet expanded on this hypothesis by examining how the immune system's cytotoxic T cellsthat is white blood cells specialized in killing cancer cellsrespond to exercise. They divided mice with cancer into two groups and let one group exercise regularly in a spinning wheel while the other remained inactive.
The result showed that cancer growth slowed and mortality decreased in the trained animals compared with the untrained. Next, the researchers examined the importance of cytotoxic T cells by injecting antibodies that remove these T cells in both trained and untrained mice.
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The antibodies knocked out the positive Systen of exercise on both cancer growth and survival, which according to the researchers demonstrates the significance of these T cells for exercise-induced suppression of cancer. The researchers also transferred cytotoxic T cells from trained to untrained mice with tumors, which improved their prospects compared with those who got cells from untrained animals. To examine how exercise influenced cancer growth, the researchers isolated T cells, blood and tissue samples after a training sessions and measured levels of common metabolites that are produced in muscle and excreted into plasma at high levels during exertion. Some of these metabolites, such as lactate, Stucy the metabolism of the T The Factor Surveillance System and increased their activity.
The researchers also found that T cells isolated from Stidy exercised animal showed an altered metabolism compared to T cells from resting animals. In addition, the researchers examined how these metabolites change in response to exercise in humans. A Study On The System took blood samples from eight healthy men after 30 minutes of intense cycling and noticed that the same training-induced metabolites were released in humans. Your feedback will go directly to Science X editors. Thank you for taking your time to send in your valued opinion to Science X editors. You can be assured our editors closely monitor every feedback sent and will take appropriate actions. Your opinions are important to us. We do not guarantee individual replies due to extremely high volume of correspondence. E-mail the story Study shows how exercise stalls cancer growth through the immune system Your friend's email Your email I would like to subscribe to Science X Newsletter. Learn more Your name Note Your email address is used only to let the recipient know who sent the email.
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