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November 13, Moles live a tough life underground.

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As a result, they've evolved helpful adaptations, such as excavator-like claws. Female moles in particular have evolved an unusual strategy: high levels of the male hormone testosterone. This is an evolutionary advantage. It produces stronger muscles for digging and foraging and aggression, to help mothers defend themselves and their young. Most of the year, female moles look and behave like males. They have masculinised genitals, with no external vagina and an enlarged clitoris. But when mating season comes, testosterone levels drop and a vagina is formed; mating Discouraging High Testosterone Levels birth follow. How they accomplish this remained a mystery for a long time. But now, the complete sequencing of the mole genome has revealed the genetic tweaks underpinning this strange cycle in female moles, by which reproductive organs gonads develop and hormones are produced. Male development in humans and other mammals is determined by chromosomes the structures within cells of living things that contain genes.

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Females have two copies of an X chromosome. Males have a single X and a male-specific Y chromosome. SRY turns on testis genes and turns off ovary genes to transform a ridge of cells into a Discouraging High Testosterone Levels. In the testis, one cell type becomes specialized to make sperm and another Leydig cells makes male hormones, including testosterone. Testosterone is responsible for the most visible sex differences in males, such as bigger bodies, more muscle mass, male genitalia and more aggression. In XX embryos, an alternate pathway makes an ovary, which pumps out estrogen. So in mammals, different genetic pathways drive the same Lebels of embryonic tissue to become either an ovary or a testis.

Discouraging High Testosterone Levels

Generally, there's no in-between. Init was discovered the basis for "intersex development" in female moles is a gonad with both ovarian and testicular tissue. Like other male mammals, male moles have a Y chromosome, bearing the SRY gene which directs testis formation. Also like other mammals, female moles lack a Levsls chromosome. Curiously, however, instead of developing ovaries they develop "ovotestes," with ovarian tissue at one end and testicular tissue at the other. The ovarian tissue source eggs and gets larger during breeding, then regresses.

The testicular tissue is full of Leydig cells that make testosterone but not sperm. Outside of breeding season, it expands until it's Discouraging High Testosterone Levels than the ovarian end. This explains why female moles have male-like genitalia, and are muscular and aggressive.

Discouraging High Testosterone Levels

But how does a patch of testis form in female moles if https://amazonia.fiocruz.br/scdp/blog/purpose-of-case-study-in-psychology/analysis-of-al-shabaab-s-origins.php have no SRY gene to trigger the process? To look for genetic changes that could allow this to happen, a global consortium of scientists sequenced the entire mole genome. They found no differences between moles and other mammals in the protein products of the odd genes involved in sex determination. However, they did discover mutations that altered the regulation of two of these genes in female moles. In all mammals, this gene switches on testis growth in XY embryos and inhibits Discouraging High Testosterone Levels that determine ovarian development.]

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