Analysis of Cancer The Enemy Within Video
RIDDLE ME THIS - Batman: The Enemy Within - Season 2 - Episode 1 Analysis of Cancer The Enemy Within
About half of all cancers have somatic integrations of retrotransposons.
Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2, cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes PCAWG project. Long interspersed nuclear element LINE-1; L1 hereafter insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers.
Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage-fusion-bridge cycles, leading to high-level amplification of oncogenes.
These observations illuminate a relevant role of L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors. Abstract About half of all cancers have somatic integrations of retrotransposons. Publication types Research Support, N. Substances Retroelements.]
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