Assured it: Lupus Case Study Overview Lupus
| Culture Culture And Anarchy | 1 day ago · Impact of autoimmune cytopenias on severity of childhood-onset systemic lupus erythematosus: A single-center retrospective cohort study Overview of attention for article published in Lupus, October 5 days ago · Brief Summary:This study will investigate BMS to assess its effects in patients with systemic lupus erythematosus (SLE). Oct 28, · Lupus Case Study Overview: Lupus Words | 9 Pages. Lupus Case Study Overview There are several types of lupus, but the most common and severe type is called Systematic Lupus Erythematosus or SLE. This form of lupus is an autoimmune disease that causes a chronic inflammation that can affect many major organs in the body. |
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Lupus Case Study Overview Lupus - you uneasy
Relatively well-established causal associations together with some new plausible causal associations were observed. Based on numerous case reports and several epidemiologic studies, more than drugs from more than 10 drug classes are suspected to cause drug-induced lupus erythematosus. Patients with CLE and patients with SLE were matched on age and sex, with individuals from the general population serving as controls. Many associations were likely due to protopathic bias. Furthermore, the results highlight that the reported associations in the published literature may be due to publication or protopathic bias. Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response. Lupus Case Study Overview Lupus.
Trial Purpose and Description
Systemic lupus erythematosus SLE and bullous pemphigoid BP are chronic autoimmune diseases in which B cells play an important pathogenic role in the different stages of the disease. B cell-targeted therapies have been suggested as a new rational approach for treating SLE. Animal models and Oevrview few case reports have supported the efficacy of the combined use of RTX followed by BLM as maintenance therapy in severe lupus nephritis LNsuggesting that their combined use may be more effective than their single use, without compromising safety. In this study, we describe the clinical case of a SLE patient with predominant renal involvement in overlap with BP, refractory to conventional therapy including RTX alone, achieving Czse steroid sparing and clinical remission under sequential treatment of RTX-BLM. This case report may encourage Lupus Case Study Overview Lupus clinical research studies in B lymphocyte targeted combination therapy in patients affected by SLE with major organ involvement or with refractory disease, suggesting that RTX and BLM sequential therapy may be a valid option for the treatment of SLE manifestations, including conventional therapy and RTX-resistant LN.
Eligibility Criteria
Systemic lupus erythematosus SLE and bullous pemphigoid BP are chronic autoimmune diseases in which B lymphocytes play a primary pathogenic role as they are implicated in the induction and progression of these diseases 12. Only a few cases of patients affected by SLE in Lupus Case Study Overview Lupus with BP have been described in the literature 3 — 5. B cells exert their pathogenic action not only by producing autoantibodies but also by presenting autoantigens to T lymphocytes and secreting of a wide variety of proinflammatory cytokines, thus perpetuating the activation of the immune system 6.
Rituximab RTXa chimeric monoclonal antibody that targets CD20 antigen on B cells, is successfully Lupus Case Study Overview Lupus to treat various autoimmune diseases by depleting B lymphocytes. Moreover, RTX has been shown to be effective in BP patients who were unresponsive or with unacceptable side effects to conventional immunosuppressive drugs 11 — Moreover, BLM has been proven to be effective to treat moderate SLE with skin, articular, and hematologic abnormalities 19although it is not licensed to treat severe lupus nephritis LN 20 — Animal models 23 and few case reports support the efficacy of the combined use of RTX followed by BLM as maintenance therapy in severe LN 24 — 27suggesting that their combined use may be more effective than their single use, without compromising safety.
In this study, we reported the clinical case of a SLE patient with predominant renal involvement in overlap with BP, refractory to conventional therapy including RTX alone, achieving significant steroid sparing and clinical remission under sequential treatment of RTX-BLM. A treatment with hydroxychloroquine HQC mg daily and acetylsalicylic acid mg daily was started. Inthe patient developed diffuse bullous skin lesions and a skin biopsy of a trunk lesion showed a typical histological picture for BP.
Therefore, topical and oral steroid 0. Subsequently, the patient developed periorbital and lower limb edema, with proteinuria 6. Inafter steroid discontinuation, the patient experienced a proteinuric flare 2.
Publications
A second renal biopsy was performed confirming the previous histological nephritis class, and the repetition of skin biopsy documented a histological picture of leukocytoclastic vasculitis in overlap with BP. Oral prednisone was restarted at a dose of 0. In December and Julytwo further retreatments with RTX were performed, with partial clinical response.]
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