Pity: Maths Level Internal Assessment Elimination Of Drug
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Maths Level Internal Assessment Elimination Of Drug Video
Pharmacokinetics: Vd, Clearance, Half-life: Calculation Drug Distribution, Elimination, RateMedically reviewed by Drugs. Last updated on July 1, Programmed delivery in vivo of 0. Clonidine transdermal system USP provides continuous systemic delivery of clonidine USP for 7 days at an approximately constant rate.
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Clonidine USP is a centrally Leveel alpha-agonist hypotensive agent. It Maths Level Internal Assessment Elimination Of Drug an imidazoline derivative with the chemical name 2, 6-dichloro-Nimidazolidinylidenebenzenamine and has the following chemical structure:. Clonidine transdermal system USP is a multi-layered film, 0. The system areas are 4. The composition per unit area is the same for all three doses. The inactive ingredients are: aluminum, colloidal silicon dioxide, ethylene vinyl acetate copolymer, light mineral oil, microporous polypropylene membrane, pigmented polyethylene polyester film, polyisobutylene and silicon coated polyester film. Proceeding from the visible surface towards the surface attached to the skin, there are four consecutive layers: 1 a backing layer of polyester film; 2 a drug reservoir; 3 a microporous polypropylene membrane that controls Eilmination rate of delivery of clonidine USP from the system to the skin surface; 4 an adhesive formulation.
Prior to use, a protective slit release liner of silicone coated polyester film that covers the adhesive layer is removed.
Clonidine Patch Description
The energy for drug release is derived from the concentration gradient existing between a saturated solution of drug in the system and the much lower concentration prevailing in the skin. Clonidine USP flows in the direction of the lower concentration at a constant rate, limited by the Mtahs membrane, so long as a saturated solution is maintained in the drug reservoir. Following system application to intact skin, clonidine USP in the adhesive layer saturates the skin site below the system.
Clonidine USP from the drug reservoir then begins to flow through the rate-controlling membrane and the adhesive layer of the system into the systemic circulation via the capillaries beneath the skin. Therapeutic plasma clonidine USP levels are achieved 2 to 3 days after initial application of clonidine transdermal system USP. The 4.
To ensure constant release of drug for 7 days, the total drug content of the system is higher than the total amount of drug delivered. Application of a new system Eliminaton a fresh skin site at weekly intervals continuously maintains therapeutic plasma concentrations of clonidine USP. If the clonidine transdermal system USP is removed and not replaced with a new system, therapeutic plasma clonidine USP levels will persist for about 8 hours and then decline slowly over several days.
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Over this time period, blood pressure returns gradually to pretreatment levels. Clonidine stimulates alpha-adrenoreceptors in the brain stem.
This action results in reduced sympathetic outflow from the central nervous system and in decreases in peripheral resistance, renal vascular resistance, heart rate, and blood pressure. Renal blood flow and glomerular filtration rate remain essentially unchanged. Normal postural reflexes are intact; therefore, orthostatic symptoms are mild and infrequent.
During long-term therapy, cardiac output tends to return to control values, while peripheral resistance remains decreased. Slowing of the pulse rate has been observed in most patients given clonidine, but the drug does not alter normal hemodynamic responses to exercise.]
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