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Revisions were made on December 23, to reflect recent data supporting increased risk of severe illness among persons with Down syndrome from the virus that causes COVID Revisions also include addition of sickle cell disease and chronic kidney disease to the conditions that might increase the risk of severe illness among children. The below list of underlying medical conditions is not exhaustive and only includes conditions with sufficient evidence to draw conclusions ; it is a living document that may be updated at any time, subject to potentially rapid change as the science evolves. This list is meant to inform clinicians to help them provide the best care possible for patients, and to inform individuals about their level of risk so they can make individual decisions about illness prevention. COVID is a new disease. Currently there are limited data and information about the impact of many underlying medical conditions on the risk for severe illness from COVID Want to see the evidence behind these lists? Children with underlying medical conditions are at increased risk for severe illness compared to children without underlying medical conditions. Current evidence on which underlying medical conditions in children are associated with increased risk is limited. Children with the following conditions might be at increased risk for severe illness: obesity, medical complexity, severe genetic disorders, severe neurologic disorders, inherited metabolic disorders, sickle cell disease, congenital since birth heart disease, diabetes, chronic kidney disease, asthma and other chronic lung disease, and immunosuppression due to malignancy or immune-weakening medications. How to Prepare and Present a Case

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