Genetically Green Fluorescent Escherichia Coli - amazonia.fiocruz.br

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Type 1 pili have long been considered the major virulence factor enabling colonization of the urinary bladder by uropathogenic Escherichia coli UPEC. The molecular pathogenesis of pyelonephritis is less well characterized, due to previous limitations in preclinical modeling of kidney infection. Here, we demonstrate in a recently developed mouse model that beyond bladder infection, type 1 pili also are critical for establishment of ascending pyelonephritis. The mannosylated extracellular domain of human DSG2 bound directly to the lectin domain of FimH in vitro , and introduction of a mutation in the FimH mannose-binding pocket abolished binding to DSG2. Our results broaden the biological importance of FimH, specify the first renal FimH receptor, and indicate that FimH-targeted therapeutics will also have application in pyelonephritis. Urinary tract infections UTIs are among the most common bacterial infections in humans. While much has been discovered about how E. Genetically Green Fluorescent Escherichia Coli

Genetically Green Fluorescent Escherichia Coli - are not

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Organofluorine compounds are known to be toxic to a broad variety of living beings in different habitats, and chemical fluorination has been historically exploited by mankind for the development of therapeutic drugs or agricultural pesticides. On the other hand, several studies so far have demonstrated that, under appropriate conditions, living systems in particular bacteria can tolerate the presence of fluorinated molecules e. Understanding the molecular mechanism behind these phenomena would greatly advance approaches to the biotechnological synthesis of recombinant proteins and peptide drugs. However, information about the metabolic effects of long-term exposure of living cells to fluorinated amino acids remains scarce. Hereby, we report the long-term propagation of Escherichia coli E.

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The response of Escherichia coli K12 upon exposure to hypochlorous acid and hydrogen peroxide English. Pietersen, B. New search for: Pietersen, B. New search for: Broeezel, V. New search for: Cloete, T. How to get this document? LUH Campus collection. There is an Open Access version for this licensed article that can be Geneticaally free of charge and without license link. The content of the Open Access version may differ from that of the licensed version. To NOA image database Close.]