The Long Dose Of Medicine - amazonia.fiocruz.br

The Long Dose Of Medicine - have

Because of scarce vaccine, the United Kingdom has stretched the interval between doses. Desperate to tame a massive surge in cases and alarmed by the spread of a new, more contagious variant of the virus, U. But Bieniasz and other virologists worry that extending the dosing interval might result in millions of people with only partial immunity as they wait for their second dose—a potential breeding ground for vaccine-resistant mutations. Yet the record case counts also create an exceptional milieu—with untold billions of viral replications occurring every second—for mutations to arise as the virus makes errors in copying its genetic alphabet. One viral variant , first spotted in South Africa, has evolved two mutations that block the effectiveness of antibodies used to treat COVID, raising the specter that they could also block vaccine-induced antibodies. One of those mutations reduced by fold or more the ability of antibodies from some recovered COVID patients to neutralize viruses expressing the coronavirus spike protein, according to a recent preprint by Jesse Bloom and Allison Greaney of the Fred Hutchinson Cancer Research Center and their colleagues. Virologists worry lengthening the dosing interval from, say, 3 weeks to 3 months, could speed the emergence of such mutants by creating a pool of subimmune people who have enough antibodies to slow the virus and avoid developing symptoms—but not enough to wipe it out. Those people might incubate viruses with mutations that allow them to dodge vaccine-induced antibodies—for example, by changing the amino acid sequence at a site where antibodies previously bound, preventing the virus from invading cells and replicating. Some data support the possibility that partial immunity could spawn new variants. For example, a case study published recently in The New England Journal of Medicine reported how, in a prolonged, ultimately fatal case of SARS-CoV-2 in an immunocompromised man, the virus kept mutating at a rapid rate compared with virus circulating in the general population. The Long Dose Of Medicine

Study record managers: refer to the Https://amazonia.fiocruz.br/scdp/essay/media-request-css/analysis-of-katherine-shonfield-s-walls-have.php Element Definitions if submitting registration or The Long Dose Of Medicine information.

Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms x. Save this study. Warning You have reached the maximum number of saved studies Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Last Update Posted : January 22, Study Description.

Arms and Interventions. Outcome Measures. Fever, fatigue, headache, chills, vomiting, diarrhea, new or worsened muscle pain, and new or worsened joint pain as self-reported on electronic diaries.

Pain at the injection site, redness, and swelling as self-reported on electronic diaries. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.

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Participants who are willing and able to comply with all scheduled visits, vaccination plan, laboratory tests, lifestyle considerations, and other study procedures. Healthy participants who are determined by medical history, physical examination, and clinical judgment of the investigator to be eligible for inclusion in the study. Phase 1 only: Individuals with a history of autoimmune disease or an active autoimmune disease requiring therapeutic intervention. Bleeding diathesis or condition associated with prolonged bleeding that would, in the opinion of the investigator, contraindicate intramuscular injection.

Women who are pregnant or breastfeeding. Previous vaccination with any coronavirus vaccine.

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Individuals who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, eg, for cancer or an autoimmune disease, or planned receipt throughout the study. Previous participation in other studies involving study intervention containing lipid nanoparticles.

Investigator site staff or Pfizer employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members. Contacts and Locations.

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Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. Lewis Research, Inc. More Information.]