Symptoms And Treatment Of Acute Pharyngitis - amazonia.fiocruz.br

Symptoms And Treatment Of Acute Pharyngitis Video

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Most AP patients' who present to the ED are interested in relief their sore throat pain. There are different approaches available in the literature to control AP pain. Studies have shown that the use of systemic glucocorticoids significantly decreases patients' sore throat. Up to our knowledge, there are no available trials looking at the role of nebulized glucocorticoids in treating infective AP.

Method: The investigators are planning to conduct a multi-center, double-blind randomized control trial.

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There will be three arms; first arm: nebulized Budesonide, second arm: nebulized Dexamethasone and third arm: placebo nebulized Normal Saline NS. The patients will be followed up for 15 days through phone calls to assess the primary and secondary outcomes. Our primary objective is to investigate whether the use of a single dose of nebulized glucocorticoids compared with placebo leads to significant improvement or complete resolution of the sore throat within 24hrs. Our secondary objectives are to assess if a single dose of glucocorticoids will: reduce sore throat at 48 hours, reduce absence from work or school, reduce the incidence of hospital admission, and reduce the rate of re-attendance to ED. Since there is Pharyngotis available data about the effect of Symptoms And Treatment Of Acute Pharyngitis glucocorticoids in AP, the appropriate sample size will be calculated after running a pilot study.

The data will https://amazonia.fiocruz.br/scdp/essay/calculus-on-manifolds-amazon/the-second-world-war-i.php recorded in the EpiData software.

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Then the data will be analyzed using the SPSS software. The ethical approval was sought from the ethical committee in each participating hospital and they approved it.

Results: The result of this study will be presented in local conferences as well in international conferences. The investigators will aim to publish the study in a well-known international emergency medicine journal. Clinical application: up to our knowledge this study is the first study worldwide looking at the effect of nebulized glucocorticoids in patients with infective acute pharyngitis.

As mentioned earlier that there are multiple approaches available in the literature to control sore throat pain and if our hypothesis turned to be correct then another alternative treatment can be added. The investigators believe that the use of Symptoms And Treatment Of Acute Pharyngitis route to administer glucocorticoids is more convenient for physicians and have less chance to develop adverse effect in comparison to systemic steroids. In the United States USAthere are approximately 12 million visits to health institutions due to acute pharyngitis 1.

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Although there are variable etiologies for AP, viral infections are the commonest 3. Symptoms of AP vary in the severity but the most common symptom for which the patients seek medical care is a sore throat. The patient may complain Treatmet fever, flu symptoms, odynophagia painful swallowingneck pain, poor oral intake, nausea, and vomiting. Different approaches were suggested to control AP pain.

It is well established that oral acetaminophen and ibuprofen are effective in decreasing AP pain 5.

There is no evidence that a particular topical lozenge or spray is superior in efficacy 6. Systemic glucocorticoids have been proven to be effective in decreasing AP sore throat. Systemic reviews and meta-analysis studies showed that a single dose of systemic glucocorticoids decreases pain within 24 hours by two times Phsryngitis at 48 hours by 1. A recently published trial showed that the use of systemic glucocorticoids in less severe acute pharyngitis significantly result in complete resolution of a sore throat at 48hours 9.]