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Descriptive Epidemiological Analysis Of Lyme Disease Essay
Beran,1 N. De Clercq,2 I. Dieussaert,2 and C. The study design took into consideration the Good Clinical PracticeGuidelines in operation at the time of initiation of the study. Informedconsent was obtained from each subject's parents or guardians. Reprints or correspondence: Dr. There has been a steady increase in the number ofcases reported to the Centers for Disease Control and Prevention from cases in [2] to 16, cases in [1]. The highest attack rates areamong children aged 14 years and adults 30 years old [1].
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A recombinant vaccine containing 30 g of the lipoprotein outer-surfaceprotein A OspA of B. A clinical trial including children years old showed thattheLyme disease vaccine was well tolerated and highly immunogenic [6]. Descriptive Epidemiological Analysis Of Lyme Disease vaccination of choice appeared to be a g dose following a 2-doseschedule. A large-scale clinical trial to evaluate the safety andimmunogenicity of the vaccine in children and adolescents years old isunder way in the United States. We report the results of a single-blind,phase 2 clinical trial of 2 doses of the vaccine in children 25 years old when the children link completed their childhood vaccination programs ; thevaccine was administered on a month schedule.
At this age, children arehigh risk for contracting Lyme disease [1]. Study design. This was a single-blind subject remained blinded todose level study conducted at 1 center.
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The subjects were randomized into 2groups and received 2 here of Lyme disease vaccine containing either 15 gor 30 g of recombinant lipoprotein OspA with aluminum. Safety andreactogenicity were assessed after each dose was administered,immunogenicity was assessed at month 2, and persistence of the immuneresponse was assessed at month 6.
The Lyme disease vaccine used in this study containedeither 15 g or 30 g of lipoprotein OspA expressed in recombinant Escherichiacoli and absorbed on 0. The vaccinescontained 2-phenoxyethanol as a preservative.
Details of the expression andpurification have been described by Van Hoecke et al.]
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