The Effect of Atm on the Operation Video
ATM - How It's Made The Effect of Atm on the OperationStroke is a complex disease that affects different brain regions, leading to disruption of abundant neural circuits, and it involves complicated injury cascade responses 1.
Ischemic stroke causes a complex pathophysiological response including destruction of the neurovascular unit, neuronal death and inflammation 34. Rapid supply of cerebral blood flow is the primary target of ischemic stroke treatment and the prerequisite for neuroprotective therapies 5.
Except for tissue plasminogen activator tPAfew pharmacological agents have succeeded in clinical trials. Therefore, the search for promising neuroprotective compounds to restore cerebral blood flow and improve neurological deficits after ischemic stroke to overcome the clinical therapeutic limitations remains an urgent issue. By means of unique advantages of label free, molecular specificity, high-throughput analysis, simple sample preparation, and in situ positioning 7At plays an irreplaceable role for measuring the spatial distribution of small molecules 89metabolites 10proteins 11peptides 12lipids Operatiojor drugs Panax notoginseng, is a traditional Chinese medicinal plant that has a long history of use in China for preventing and treating ischemic cerebrovascular diseases The current research on Panax notoginseng mainly focuses on the roots of Panax notoginseng.
However, the stem and leaf parts of Panax notoginseng are often ignored. The Effect of Atm on the Operation leaf triterpenes PNGL is the total saponins extracted from the stem and leaf of Panax notoginseng, which has the functions of regulating blood lipid, sedative and hypnotic, analgesic, anti-inflammatory, and anti-aging 17 - More https://amazonia.fiocruz.br/scdp/essay/benedick-and-beatrice-argument-quotes/who-is-the-best.php, our previous studies have mainly reported the neuroprotective effect of PNGL after ischemic stroke in the inhibition of inflammation and apoptosis However, the mechanism of PNGL on brain metabolic small molecules and their spatial distributions remain unsystematic explored.
Introduction
Additionally, chemical fingerprinting data have revealed that the content of total saponins of Panax notoginseng stems and leaves are mainly protopanaxadiol-type saponins, and contains almost no protopanaxatriol-type saponins As shown in Figure S1A,Bmonomeric saponins contained in protopanaxadiol-type saponins mainly include ginsenoside Rb1, ginsenoside Rc, ginsenoside Rb2, and ginsenoside Rb3.
Before study, they were freshly dissolved in 0. At 24 h after reperfusion, some brain tissues were fixed for histopathology and small molecule metabolism detection. After MCAO surgery, the wound was disinfected with iodine, and then the wound was sutured with sterile surgical suture to reduce the bleeding. We also injected tramadol 2. Reperfusion was induced for 24 h by removing the suture.
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Rats in the sham group were operated using the same method but with no occlusion in middle cerebral artery. Neurological performances of all animals were performed by two blinded investigators using a 5-point scale following a previously described method The neurological function was scored according to a series of scales from 0 to 4. The highest score represents the most severe neurological deficits. Histopathology staining 24 h postreperfusion was implemented as reported previously Analogously, as shown in Figure 1F,GNissl staining from each group were also detected under a light microscope.]
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