Atherosclerosis Pulmonary Abnormal Level Of Blood Lipids Video
Atherosclerosis – Artery Disease, Plaque Formation, Risk Factors and Prevention (Pathophysiology)Atherosclerosis Pulmonary Abnormal Level Of Blood Lipids - rather valuable
Atherosclerosis is a disease in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheromatous plaque. The exact cause is not known. Prevention is generally by eating a healthy diet , exercising, not smoking, and maintaining a normal weight. Atherosclerosis generally starts when a person is young and worsens with age. The following terms are similar, yet distinct, in both spelling and meaning, and can be easily confused: arteriosclerosis , arteriolosclerosis , and atherosclerosis.
Atherosclerosis Pulmonary Abnormal Level Of Blood Lipids
December 21, Atherosclerosis is the result Atherosclreosis a buildup of lipids in the inner walls of blood vessels, and is a major cause of heart disease and stroke. In a new study, researchers from the University of Tsukuba discovered a novel role for cAMP responsive element-binding protein 3 like 3 CREB3L3 in the development of atherosclerosis and identified a mechanism by which it exhibits protective effects against atherosclerosis. Atherosclerosis is the detrimental result of long-time high blood lipid levels leading to a thickening of the inner walls of blood vessels through the formation of a so-called plaque.
As a result, blood flow to the brain and heart may decrease over time, and once the plaque ruptures, platelets in the blood stream aggregate and clog the blood vessel as they try to repair the damage. While a number of proteins and mechanisms are known to play a part in the development of atherosclerosis, research is ongoing to fully understand this complex process. CREB3L3 is a transcription factor, which is a protein that binds to DNA and regulates gene expression in the liver and small intestineand plays an important role in the hepatic triglyceride and glucose metabolism.
To achieve their goal, the researchers looked into how the absence or the overexpression of CREB3L3 would affect the development of atherosclerosis. To investigate the absence of CREB3L3, the Atherosclerosis Pulmonary Abnormal Level Of Blood Lipids generated knockout mice that were deficient in the protein in the liver or intestines, or both.
To investigate the overexpression, the researchers generated a transgenic mouse overexpressing CREB3L3 in the liver. Because atherosclerosis does not naturally occur in mice, the researchers made use of a mouse line, in which the receptor of LDL cholesterol LDLRcommonly known as "bad" cholesterol, is absent.
Reduce your risk of getting COVID-19
Because LDL cholesterol circulating in the build cannot be taken up by cells, it builds up in blood vessel walls and leads to the formation of atherosclerosis. Go here, the researchers found that absence of CREB3L3 in either the liver or intestines resulted in an exacerbation of high blood lipid levels and atherosclerosis formation, and more so in the mice, in which CREB3L3 was knocked out in both organs. Conversely, overexpressing the protein in the liver markedly suppressed blood cholesterol levels and atherosclerosis formation. By looking closer at the molecular mechanism by which CREB3L3 confers protective effects against atherosclerosis, the researchers found that it interacts with sterol regulatory element-binding protein SREBP to trap it in a cellular compartment called endoplasmic reticulum and prevent it from inducing the expression of genes important for the formation of atherosclerosis.
Explore further. Your feedback will go directly to Science X editors.
Thank you for taking your time to send in your valued opinion to Science X editors. You can be assured our editors closely monitor every feedback sent and will take appropriate actions.
What to consider before being around other people
Your opinions are important to us. We do not guarantee individual replies due to extremely high volume of correspondence. E-mail the story Protecting against atherosclerosis at the molecular level Your friend's email Your email I would like to subscribe to Science X Newsletter. Learn more Your name Note Your email address is used only to let the recipient know who sent the email. Neither your address nor the recipient's address will be used for any other purpose. The information you enter will appear in your Od message and is not retained by Medical Xpress in any form. You can unsubscribe at any time and we'll never share your details to third parties.
Navigation menu
More information Privacy policy. This site uses cookies to assist with navigation, analyse your use of our services, and provide content from third parties. By using our Atherosclrosis, you acknowledge that you have read and understand our Privacy Policy and Terms of Use. Home Medical research Home Cardiology. Credit: Cellular and Molecular Gastroenterology and Hepatology DOI: More information: Yoshimi Nakagawa et al. Provided by University of Tsukuba.
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Related Stories.]
You are absolutely right. In it something is also to me your thought is pleasant. I suggest to take out for the general discussion.
Prompt to me please where I can read about it?
Plausibly.
On your place I would arrive differently.