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E-mail: alcortajarena cicbiomagune. Metal nanoclusters NCs and their unique properties are increasing in importance and their applications are covering a wide range of areas. Their remarkable fluorescence properties and easy synthesis procedure and the possibility of functionalizing them for the detection of specific targets, such as biomarkers, make them a very interesting biosensing tool. Nowadays the detection of biomarkers related to different diseases is critical. In this context, NCs scaffolded within an appropriate molecule can be used to detect and quantify biomarkers through specific interactions and fluorescence properties of the NCs. A Fluorescent Mirna Sensor For The Study A Fluorescent Mirna Sensor For The Study

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A Fluorescent Mirna Sensor For The Study

The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated. A human cytomegalovirus HCMV causes a persistent asymptomatic infection in healthy individuals and possesses unexpected dangers to newborn babies, immunocompromised people, and organ transplant recipients because of stealth transmission. Thus, an early and accurate diagnosis of HCMV infection is crucial for prevention of unexpected transmission and progression of the severe diseases.

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The standard method of HCMV diagnosis depends on serology, antigen test, and polymerase chain reaction-based nucleic acid detection, which have advantages for each target molecule. However, the serological test for an antibody is an indirect method Sensorr the past virus infection, and antigen and viral nucleic acid testing demand laborious, complex multistep procedures for direct virus detection.

Herein, we present an alternative simple and facile fluorometric biosensor composed of a graphene oxide nanocolloid and fluorescent peptide nucleic acid PNA probe to detect the HCMV infection by simply monitoring the virally encoded microRNA as a new biomarker of https://amazonia.fiocruz.br/scdp/essay/mormon-bank-utah/on-wednesday-march-15-2017-i-attended.php virus infection. We proceed with the time course and concentration-dependent investigation of hcmv-miRNA sensing in living cells as a direct method of HCMV detection at the molecular level on the basis of an intracellular hcmv-miRNA expression profile and graphene oxide nanocolloid-based simple diagnostic platform.

A Fluorescent Mirna Sensor For The Study

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Sensoe by Ji-Seon Lee. More by Seongchan Kim. More by Sungchul Kim.]

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