Research Database. Impact of thrombogenic mutations on clinical phenotypes of von Willebrand disease. Clinical phenotype of bleeding disorders modulated to a decrease in bleeding symptoms by thrombogenic mutations.
Genotypic analysis was performed using polymerase chain reaction PCR and restriction fragment length polymorphism. Forty-five patients Eight patients with VWD were carrying the defective alleles of different thrombogenic markers, showing milder phenotypes than expected.
Hence, we concluded that thrombophilic markers were seen to be influencing the clinical phenotypes of patients with VWD.]
I agree with you