Major Depressive Disorder Mdd - amazonia.fiocruz.br

Major Depressive Disorder Mdd - question

Depression is a state of low mood and aversion to activity. It may feature sadness, difficulty in thinking and concentration and a significant increase or decrease in appetite and time spent sleeping. People experiencing depression may have feelings of dejection, hopelessness and, sometimes, suicidal thoughts. It can either be short term or long term. Adversity in childhood, such as bereavement , neglect , mental abuse , physical abuse , sexual abuse , or unequal parental treatment of siblings can contribute to depression in adulthood. Life events and changes that may influence depressed moods include but are not limited to : childbirth , menopause , financial difficulties, unemployment, stress such as from work, education, family, living conditions etc. Changes in personality or in one's social environment can affect levels of depression. Major Depressive Disorder Mdd

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Major depressive disorder MDD is a prevailing chronic mental disorder with lifetime recurring episodes. Recurrent depression RD has been reported to be associated with greater severity of depression, higher relapse rate and prominent functioning impairments than first-episode depression FEDsuggesting the progressive nature of depression.

However, there is still little evidence regarding brain functional connectome. After six months of treatment with paroxetine, 56 patients achieved clinical remission and finished their second scan.

Network-based statistics analysis was used to explore the changes in functional connectivity. The results revealed that, compared with Mfd, patients with FED exhibited hypoconnectivity in the somatomotor, default mode and dorsal attention networks, and RD exhibited hyperconnectivity in the somatomotor, salience, executive control, default mode and dorsal attention networks, as well as within and between salience and executive control networks.

Moreover, the disrupted components in Major Depressive Disorder Mdd with current MDD did not change significantly when the patients achieved remission after treatment, and sub-hyperconnectivity and sub-hypoconnectivity were still found in those with remitted RD. Mjaor, the hypoconnectivity in FED and hyperconnectivity in RD were associated with the number of episodes and total illness duration. This study provides initial evidence supporting that impairment of intrinsic functional connectivity across the course of depression is a progressive process. Abstract Major depressive disorder MDD is a prevailing chronic mental disorder with lifetime recurring episodes.]