Cardiac Hypertrophy Athlete s Heart - amazonia.fiocruz.br

Cardiac Hypertrophy Athlete s Heart - intolerable

Illustrations of a normal heart left and a heart with hypertrophic cardiomyopathy HCM. Note that the muscular heart walls septum are much thicker hypertrophied in the HCM heart. Hypertrophic cardiomyopathy HCM is a disease in which the heart muscle becomes abnormally thick hypertrophied. The thickened heart muscle can make it harder for the heart to pump blood. Hypertrophic cardiomyopathy often goes undiagnosed because many people with the disease have few, if any, symptoms and can lead normal lives with no significant problems. Cardiac Hypertrophy Athlete s Heart

Cardiac Hypertrophy Athlete s Heart Video

A Heart for Endurance: One Cyclist's Story With HCM

Data Functional Genomics data. Functional Characterization data.

Publications production. The Journal of clinical investigation. Abstract RNA splicing is a major contributor to Cardic transcriptome complexity; however, the functional role and regulation of splicing in heart failure remain poorly understood. Here, we used a total transcriptome profiling and bioinformatic analysis approach and identified a muscle-specific isoform of an RNA splicing regulator, RBFox1 also known as A2BP1as a prominent regulator of alternative RNA splicing during heart failure.

Evaluation of developing murine and zebrafish hearts revealed that RBFox1 is induced during postnatal cardiac maturation. However, we found that RBFox1 is markedly diminished in failing human and mouse hearts. In a mouse model, RBFox1 deficiency in the heart https://amazonia.fiocruz.br/scdp/essay/writing-practice-test-online/the-transitional-period-between-the-two-traditions.php pressure overload-induced heart failure. We determined that RBFox1 is a potent regulator of RNA splicing and is required for a conserved Hypertropuy process of transcription factor MEF2 family members that yields different MEF2 isoforms with differential effects on cardiac hypertrophic gene expression.

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Finally, induction of RBFox1 expression in murine pressure overload models substantially attenuated cardiac hypertrophy and pathological manifestations. Together, this study identifies regulation of RNA splicing by RBFox1 as an important player in transcriptome reprogramming during heart failure that influence pathogenesis of the disease.

References PMID]