Alpha Spectroscopy Is A Technique For Quantification - amazonia.fiocruz.br

Alpha Spectroscopy Is A Technique For Quantification Video

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Alpha Spectroscopy Is A Technique For Quantification - think, what

ACS Nano In press. Lipids are a major source of energy for most tissues, and lipid uptake and storage is therefore crucial for energy homeostasis. So far, quantification of lipid uptake in vivo has primarily relied on radioactive isotope labeling, exposing human subjects or experimental animals to ionizing radiation. Here, we describe the quantification of in vivo uptake of chylomicrons, the primary carriers of dietary lipids, in metabolically active tissues using magnetic particle imaging MPI and magnetic particle spectroscopy MPS. Importantly, by utilizing highly magnetic Zn-doped iron oxide nanoparticles ZnMNPs , we generated ACM with MPI tracer properties superseding the current gold-standard, Resovist, enabling quantification of lipid uptake from whole-animal scans. Alpha Spectroscopy Is A Technique For Quantification

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Ochronosis can be visible externally in the ear cartilage and sclera of the eyes; however, these sites are subject to less loading than internal tissues such as joints, spine and tendons which are subject to load-stresses.

Other debilitating manifestations of AKU are due to ochronosis including premature arthritis, cardiac valve disease, fractures, muscle and tendon ruptures. Recently, nitisinone, an inhibitor of p-hydroxyphenylpyruvate dioxygenase EC AKU is not fully reversible, even though a recent study has click evidence of significant reversal of ochronosis in the eyes and ears Ranganath et al. This has been addressed in the National Alkaptonuria Centre NAC by a minimally invasive ear biopsy 4 mm disc Fro ear cartilage samples Specctroscopy is then subject to quantitative analysis for ochronotic pigment.

There are several limitations of the ear biopsy approach. These include a relatively small area of sampling, not therefore representing the totality of ochronosis present in the ear, which is often heterogeneous in distribution.

Quantification of Lipoprotein Uptake in Vivo Using Magnetic Particle Imaging and Spectroscopy

Further, there is a limitation on the number of times ear biopsy can be reliably performed during follow-up. We have recently investigated Raman for the analysis of ochronosis on ex vivo samples Taylor et al. It is likely that this technique could be adapted for non-invasive monitoring of ear cartilage and Achilles tendons in the NAC and this will be the major focus of this PhD programme.

As well as assessing the development of ochronosis on ex vivo samples https://amazonia.fiocruz.br/scdp/essay/perception-checking-examples/avon-is-an-american-international-manufacturer.php Raman microscopy, hand-held portable Raman spectrometers, including spatially offset Raman spectroscopy SORSwill be developed for point-of-care POC use. If successful, POC-based Raman spectroscopy will allow annual serial monitoring of ear cartilage and Achilles tendons for change in ochronosis.

Ellis, D. Analyst Ranganath L. J Inherit Metab Dis 42, JIMD Reports. DOI: Osteoarthritis Cartilage 27, Undergraduate enquiries. International enquiries.]