Congratulate: A Research Study On Zika Virus
| A Research Study On Zika Virus | 5 days ago · A preclinical study by a University of South Florida Health (USF Health) Morsani College of Medicine research team has discovered a new mechanism for how Zika virus can pass from . 2 days ago · In vitro study helps explain how Zika virus passes from mother to fetus during pregnancy On A preclinical study by a University of South Florida Health (USF Health) Morsani College of Medicine research team has discovered a new mechanism for how Zika virus . 6 days ago · New research findings correlate with clinical observations of more fetal abnormalities and other Zika-related health problems in late versus early pregnancy Credit: Photo courtesy of USF Health Tampa, FL (Feb. 3, ) — A preclinical study . |
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A preclinical study by a University of South Florida Health USF Health Morsani College of Medicine research team has discovered a new mechanism for how Zika virus can pass from mothers to their children during pregnancy—a process known as vertical transmission. They also report that the agent tizoxanide inhibits ZIKA virus in maternal decidual cells grown in the lab, offering promise for preventing perinatal transmission that can cause devastating malformations and brain damage in developing fetuses and infants. The study was led by co-principal investigators Ozlem Guzeloglu-Kayisli, Ph. Lockwood, MD, USF Health senior vice president, dean of the Morsani College of Medicine, and a professor of obstetrics and gynecology specializing in maternal-fetal medicine. The widespread global alarm caused by the spread of mosquito-borne Zika virus throughout the Americas in dissipated after the virus all but disappeared in
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Tampa, FL Feb. The researchers showed, for the first time, that specialized cells lining the uterus maternal decidual cells act as reservoirs for trimester-dependent transmission of the virus through the placenta - accounting for both the fetus's greater susceptibility to first-trimester Zika infection and for the more serious congenital defects observed in early versus late pregnancy. They also report that the agent tizoxanide inhibits ZIKA virus in maternal decidual cells grown in the lab, offering promise for preventing perinatal transmission that can cause devastating malformations and brain damage in developing fetuses and infants. The findings appeared Dec. Lockwood, MD , USF Health senior vice president, dean of the Morsani College of Medicine, and a professor of obstetrics and gynecology specializing in maternal-fetal medicine. The widespread global alarm caused by the spread of mosquito-borne Zika virus throughout the Americas in dissipated after the virus all but disappeared in Yet, resurgence remains possible in areas where the Aedes aegypti mosquito is prevalent, and there is no treatment or vaccine available for Zika virus infection. While most Zika-infected adults show no symptoms, the virus can cause minor flu-like symptoms, and in rare cases has been associated with Guillain-Barre syndrome. However, Zika poses the most concern for pregnant women, because up to one in 10 newborns of affected mothers suffer Zika-associated birth defects , including smaller than normal head size microcephaly that can lead to developmental disabilities and other health problems. Zika has also been linked to pregnancy complications, including preterm birth, preeclampsia and miscarriage.Health Problems
Tampa, FL Feb. They also report that the agent tizoxanide inhibits ZIKA virus in maternal decidual cells grown in the lab, offering promise for preventing perinatal transmission that can cause devastating malformations and brain damage in developing fetuses and infants. Lockwood, MD, USF Health senior vice president, dean of the Morsani College of Medicine, A Research Study On Zika Virus a professor of obstetrics and gynecology specializing in maternal-fetal medicine.
The widespread global alarm caused by the spread of mosquito-borne Zika virus throughout the Americas in dissipated after the virus all but disappeared in Yet, resurgence remains possible in areas where the Aedes aegypti mosquito is prevalent, and there is no treatment or vaccine available for Zika virus infection. While most Zika-infected adults show no symptoms, the virus can cause minor flu-like symptoms, and in rare cases has been associated with Guillain-Barre syndrome.
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However, Zika poses the most concern for pregnant women, because up to one in 10 newborns of affected mothers suffer Zika-associated birth defects, including smaller than normal head size microcephaly that can lead to developmental disabilities and other health problems. Zika has also been linked to pregnancy complications, including preterm birth, preeclampsia and Zima.
Moreover, timing appears important. Mothers infected in the first trimester are much more likely to have babies with severe Zika birth defects than mothers infected in the third semester. The placenta, the organ supplying maternal oxygen and nutrients to the growing fetus, has ways to prevent most Rssearch, including viruses, from crossing its protective maternal-fetal barrier.
A subtype of fetally-derived placental cells known as syncytiotrophoblasts, in direct contact with maternal blood, are assumed to be the site where the Zika virus enters the placenta, leading to potential fetal infection. However, Dr. Ozlem Guzeloglu-Kayisli said, these particular trophoblasts resist Zika virus attachment and replication.
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To learn more about how Zika gets through the placental wall, the USF Health team began by investigating the cellular A Research Study On Zika Virus molecular mediators of Zika virus replication. Among their key findings, the researchers:. Once inside the maternal cells, the Zika virus an RNA virus hijacks the cellular machinery to make proteins needed to copy its genetic material and churn out new viral particles. The drug has been shown preclinically to inhibit a broad range of flu-like viruses and is being tested clinically against coronavirus.
The finding warrants further testing of tizoxanide to block perinatal transmission of Zika virus and thereby protect the fetus from harmful outcomes, the researchers conclude. The University of South Florida is a high-impact global research university dedicated to student success.
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