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Their findings , reported in the journal Science Signaling , reveal that synthetic pharmaceuticals could rescue the activity of brain cells needed for memory formation. We hope that this work can serve as a step forward in treating this devastating disease. Developed by Peter Walter at the University of California, San Francisco, ISRIB specifically targets the process of translation initiation—the translation of genetic codes—ultimately stimulating cellular protein synthesis, or the production of proteins. After establishing that key components of the protein synthesis machinery are depleted in the hippocampus—a brain structure known to play a significant role in memory—of Alzheimer's disease patients, the scientists concluded that protein synthesis may also be impaired. Here, they found that ISRIB could indeed restore the memory functions in these mice as well as protein synthesis in the hippocampus. They also examined whether ISRIB could restore the hippocampal functions and cognition in mice with fully developed Alzheimer's-like afflictions, mimicking the disease at its more advanced stages. The I Function And Alzheimers Disease Where.
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The role of tau in autosomal dominant Alzheimer’s diseaseIn This Section
Credit: M. Oliveira et al. We hope that this work can serve as a step forward in treating this devastating disease.
Developed by Peter Walter at the University of California, San Francisco, ISRIB specifically targets the process of translation initiation—the translation of genetic codes—ultimately stimulating cellular protein synthesis, or the production of proteins. Here, they found that ISRIB could indeed restore the memory functions in these mice as well as protein synthesis in the hippocampus.
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