Diabetes Mellitus As A Metabolic Disorder Video
Diabetes Mellitus As A Metabolic Disorder.Anastasia Poznyak, Andrey V. Grechko, Paolo PoggioVeronika A. MyasoedovaValentina AlfieriAlexander N. Diabetes AA comprises a group of carbohydrate metabolism disorders that share a common main feature of chronic hyperglycemia that results from defects of insulin secretion, insulin action, or both. Insulin is an important anabolic hormone, and its deficiency leads to various metabolic abnormalities in proteins, lipids, and carbohydrates. Atherosclerosis develops as a result of a multistep process ultimately leading to cardiovascular disease associated with high morbidity and mortality.
Alteration of lipid metabolism is a risk factor and characteristic feature of atherosclerosis. Possible links between the two chronic disorders depending on altered metabolic pathways have been investigated in numerous studies. It was shown that both types of diabetes mellitus can actually induce atherosclerosis development or further accelerate its progression.
Elevated glucose level, dyslipidemia, and other metabolic alterations that accompany the disease development are tightly involved in the pathogenesis of atherosclerosis at almost every step of the atherogenic process.
Chronic inflammation is currently considered as one of the key factors in atherosclerosis development and is present starting from the earliest stages of the pathology initiation. It may also be regarded as one of the possible links between atherosclerosis and diabetes mellitus. However, the data available so far do not allow for developing effective anti-inflammatory therapeutic strategies that would stop atherosclerotic lesion progression or induce lesion reduction. In this review, we summarize the main aspects of diabetes mellitus that possibly affect the atherogenic process and its relationship with chronic inflammation. We also discuss the established pathophysiological features that link atherosclerosis and Diabetes Mellitus As A Metabolic Disorder mellitus, such as oxidative stress, altered protein kinase signaling, and the role of certain miRNA and epigenetic modifications.
The diabetes mellitus—atherosclerosis connection: The role of lipid and glucose metabolism and chronic inflammation. T1 - The diabetes mellitus—atherosclerosis connection: The role of lipid and glucose metabolism and chronic inflammation.
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Copyright: Copyright Elsevier B. N2 - Diabetes mellitus comprises a group of https://amazonia.fiocruz.br/scdp/essay/writing-practice-test-online/the-united-kingdom-and-the-european-union.php metabolism disorders that share a common main feature of chronic hyperglycemia that results from defects of insulin secretion, insulin action, or both.
AB - Diabetes mellitus comprises a group of carbohydrate metabolism disorders that share a common main feature of chronic hyperglycemia that results from defects of insulin secretion, insulin action, or both. Centro Cardiologico Monzino. Overview Fingerprint.
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Abstract Diabetes mellitus comprises a group of carbohydrate metabolism disorders that share a common main feature of chronic hyperglycemia that results from defects of insulin secretion, insulin action, or both. Keywords Atherosclerosis Cardiovascular disease Chronic inflammation Diabetes mellitus Hyperglycemia Lipid metabolism. Access to Document Link to publication in Scopus. Link to the citations in Scopus.
International Journal of Molecular Sciences21 5[]. International Journal of Molecular Sciences. Poznyak, Anastasia ; Grechko, Andrey V. In: International Journal of Molecular Sciences.]
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