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Carbon Nanotubes On The Delivery Of Pharmaceuticals.

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Cross-sectional high-resolution transmission electron microscope images of different polymer-coated silibinin-loaded nanotubes a polysorbate 20, b polysorbate 80, c poly- ethylene glycoland d chitosan. Each arrow points to the thin Pharmaceutlcals of biopolymer coating deposited on the outer surface of nanotubes. Credit: Nature Scientific Reports. Cancer is the second leading cause of death in the United States each year.

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Current treatment regimens using conventional chemotherapy face tremendous challenges in drug administration and drug resistance due to their poor solubility and selectivity. These limitations have prompted researchers to develop nanomaterials and nanoparticles that can be loaded with drugs to act as delivery platforms to enhance the efficacy of cancer treatment. Silibinin SILa natural derivative isolated from the medicinal plant Silybum marianum milk thistleis a promising candidate owing to its anticancer and antimetastatic activity. However, SIL drug activity is often undermined by its poor water solubility, which results in low bioavailability.

Mohd Zobir Hussein and his research team from Universiti Putra Malaysia have developed an innovative solution to overcome the solubility issue by using biopolymerized multiwalled carbon nanotubes MWCNTs to carry the SIL drug into targeted cancer cells.

The use of carboxylated carbon nanotubes coated with water-soluble polymers can improve bioavailability and biocompatibility, enabling transport of the drug molecules into mammalian cells. As reported in a recent issue of Scientific Reports doi The physicochemical characteristics of the delivery systems and efficient dispersibility of the SIL-loaded nanotubes SIL-MWCNTs with different Carbon Nanotubes On The Delivery Of Pharmaceuticals, and their cytotoxic effect on cells were evaluated.

The external polymer coating was found to be critical in maintaining thermal stability and the characteristics of SIL-carbon nanotubes compared with free drug and free uncoated nanotubes. Hence, [they] can prevent degradation of the drug and further reduce the unwanted side effect which results in greater patient compliance. This makes them a versatile drug delivery paradigm in the field of nanomedicine. Reprints and Permissions. Bio-polymerized carbon nanotubes enhance in vitro cancer drug delivery. MRS Bulletin Download citation. Published : 04 February Search Carbon Nanotubes On The Delivery Of Pharmaceuticals Search. Download PDF. Rights and permissions Reprints and Permissions. About this article. Cite this article Bio-polymerized carbon nanotubes enhance in vitro cancer drug delivery.]

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