The Viscosity Of Different Formulation At 10 - amazonia.fiocruz.br

The Viscosity Of Different Formulation At 10 Video

Being hydrophobic, paraffin wax is potentially useful for developing taste-masked or sustained release drug formulations. However, its high hydrophobicity also makes it challenging to achieve good embedment of a hydrophilic drug e. While spray congealing is an efficient technique of producing microparticles for pharmaceutical applications, there has been limited investigation on the use of paraffin Thee in this technique.

Terms & Conditions

A rapid method based on microscopic assessment was developed to screen paraffin wax blends containing surfactants for Formjlation extent of drug embedment. The rheological properties of the molten blends were investigated. Suitable blends were spray-congealed and the products characterised. Statistical analysis of the data and drug release modelling were carried out.

Access options

Drug-loaded paraffin wax was too viscous for spray congealing. The addition of surfactants decreased the melt viscosity and improved sprayability and microparticle yield. The microparticles showed high paracetamol encapsulation efficiency, with drug particles well-embedded in some formulations.

The drug release was effected through diffusion and erosion of the matrix material. The use of surfactants allowed successful embedment of paracetamol within spray-congealed microparticles, enabling taste-masking and sustained release. This is a preview of subscription content, log in to check access. Rent this article via DeepDyve. Sullivan SD.

Noncompliance with medication regimens and subsequent hospitalization: a literature analysis and cost of hospitalization estimate. J Res Pharm Econ.

Google Scholar. Ley P.

Communicating with patients : improving communication, satisfaction, and compliance. London; New York: Croom Helm; Jimmy B, Jose J. Patient medication adherence: measures in daily practice. Oman Med J. Improvement of the bitter taste of drugs by complexation with cyclodextrins: applications, evaluations and mechanisms. Ther Deliv. Andrade C. Sustained-release, extended-release, and other time-release formulations in neuropsychiatry.

Navigation menu

J Clin Psych. Sustained and controlled release drug delivery systems. Modern pharmaceutics. New York: Dekker; Are immediate- and extended-release drugs interchangeable? Acta Psychiatr Scand.]