Synaptic Of Alzheimer s Disease
Synapses are the most important compartments of neuron that deliver signals to adjacent neuron and maintain healthy synaptic functions of the brain.
1. Introduction
Synapse territories are composed of synaptic vesicles, synaptic proteins, mitochondria, neurotransmitters receptors, postsynaptic density protein and localized small RNAs and miRNAs. Recently, several studies identified the miRNAs enrichments at synapse, synaptic vesicles and synaptosomes. In the first part of our study, we will identify the synaptosome-specific miRNAs that are deregulated in AD, and further, we will characterize their roles in AD progression and pathogenesis.
Impact of synaptosomal miRNAs will be studied against A?
In second part we will determine the role of synaptosomal miRNAs in A? We will focus on neuronal processing, neuronal growth and network development and synaptic plasticity using APP primary neuronal cultures. And in third part we will study the role of synaptosomal miRNAs in phosphorylated-tau p-tau induced synaptic and cognitive dysfunction in AD. The impact of synaptosomal miRNAs will be studied on p-tau induced toxicity in neurons, healthy neurons processing, neuronal growth and network development and synaptic plasticity using tau primary neuronal culture. We will execute the synaptosome-specific miRNAs expression with various cognitive behavioral and biochemical tests in 2- 6- and month-old tau Synaptic Of Alzheimer s Disease and KO mice relative to WT mice.
MicroRNAs miRNAs enrichment was detected at synapse and synaptosomal components; however, the status of synaptosomal miRNAs and their precise roles in Alzheimer's disease progression are completely unexplored. Present study is designed to determine the status of synaptosomal and cytosolic miRNAs in Alzheimer's disease and to unveil their possible roles in amyloid-?
North America
The outcome of our study is expected to provide new insights about synaptosome- specific miRNAs and their therapeutic relevance in synaptic dysfunction in Alzheimer's disease. Toggle navigation. Abstract Funding Institution Comments.
Recent in Grantomics:. Recently viewed grants:.
Share this:
Recently added grants:. Funding Agency. Name Texas Tech University.]
I think, what is it — a serious error.
It is an excellent variant
We can find out it?
I apologise, but this variant does not approach me.
It seems, it will approach.