The Mechanism Program At Children s Hospital Video
Female Athlete Triad Update - Female Athlete Program - Sports Medicine - Boston Children's Hospital The Mechanism Program At Children s Hospital.
Cancer metastasis — the spread of disease from the original site to a distant organ — remains a major challenge in treating cancer and a main cause of morbidity and mortality. To understand metastasis, many investigators have focused on the cancer cell— or seed.
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The study will focus on a newly identified type of messenger — extracellular vesicles released by cancer cells into their environment. Exosomes are taken in by other The Mechanism Program At Children s Hospital and can modify behavior of the receiving cell. According to DeClerck, healthy cells are typically inhospitable to source cells. What causes them to change from foe to friend? The first paper, in the Journal of Extracellular Vesicles, describes research conducted during his sabbatical, spent in the lab of co-author Pascale Zimmermann in Marseille, France. His research identified how exosomes, shed by neuroblastoma cells, induce bone marrow mesenchymal progenitor cells to release factors favorable to cancer cells. A subsequent paper, recently published in Cancer Research, describes the mechanisms by which these bone marrow cells — also present in primary tumors — promote the growth of neuroblastoma cells and their resistance to chemotherapy.
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