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November 17, Prolonged androgen deprivation therapy ADT can impair cardiorespiratory fitness and increase risk of cardiovascular death in prostate cancer patients with high risk of cardiovascular disease, according to a study in JACC: CardioOncology. The findings contribute further data supporting the need for cardiovascular disease CVD monitoring in patients who are living longer after successful cancer treatment. Approximately 1 in 9 men will be diagnosed with prostate https://amazonia.fiocruz.br/scdp/blog/culture-and-selfaeesteem/time-of-the-holocaust.php during their lifetime, and it is the second leading cause of cancer death for men in the United States.
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Furthermore, CVD is a leading cause of death in men who have a history of prostate cancer. ADT with radiation therapy is a standard primary treatment for prostate cancer as an alternative to surgery and is frequently used in patients with metastatic, recurrent and localized high-risk tumors.
More prolonged use of ADT in certain patients with prostate cancer is increasingly employed following studies that demonstrated improved cancer outcomes compared to short-term ADT exposure. Authors of this Psych set out to study the association between ADT exposure and CV mortality and cardiorespiratory fitness CRFwhich is a known independent predictor of CV mortality, in patients with prostate cancer.
Researchers of this study evaluated patients from a single center, retrospective cohort who underwent an exercise treadmill test for clinical indications a median of 4.
Stages of Prostate Cancer
CV risk assessment was determined by a patient's demographics, indication for exercise treadmill test such as chest painmedical history and medication usage at the time of the Th test. Prostate cancer treatment regimens used before and after a patient's exercise treadmill test were looked at. Researchers also examined ADT treatment, including the therapy used and duration of ADT exposure prior to the treadmill test.
ADT exposure was categorized as short-term less than or equal to six months versus prolonged greater than six months. CRF was calculated from peak treadmill Ane and grade achieved during a patient's exercise treadmill test. Almost one-quarter of the patients received ADT prior to their treadmill test, with 51 patients exposed to long-term ADT use.]
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