Development Of The Human Brain
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Cerebral organoids are three-dimensional miniature organs that resemble the human brain. Derived from human pluripotent stem cells, cerebral organoids have emerged to advance stem cell research, improve three-dimensional tissue culture techniques and enhance understanding of human fetal brain development and neurological disease. Rodent models, although mechanistically useful, cannot fully capture the complex morphology, cellular diversity and neural connectivity of the human brain. In the first study of its kind, Dr.
Prenatal Development
Hester and his research team reported correlations between neuroelectrical activities and the molecular and cellular development of cerebral organoids. The study is published in Stem Cell Reports. Cerebral organoids in a petri dish. Understanding the correlation between the neuroelectrical and molecular development in cerebral organoids brings additional value to their ability to model complex neurological disorders. Such insights could lead to targeted therapies that would restore proper electrophysiological function or replace a defective gene, says Dr.
In addition, since cerebral organoids can be generated from patients, they can be used to characterize newly identified genetic variants and develop personalized treatments. Cerebral organoid research could also elucidate the influence of environmental factors, such as viral pathogens, on neuroplasticity in neonatal brain development.
Neuroelectrical activity first appeared at approximately day 30, maturing from low-amplitude spiking activity to synchronized burst firings. A surge in astrocytes was observed after months of culture.
General Brain Development
Astrocytes influence neuronal connectivity and electrophysiology, Dr. Hester explains. Currently, Dr.]
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