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Intrinsically Disordered Proteins

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Learn about cystic fibrosis, a genetic disorder that affects the lungs, pancreas, and other organs, and how to treat and live with this chronic disease. Cystic fibrosis is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over time. Without the chloride to attract water to the cell surface, the mucus in various organs becomes thick and sticky. In the lungs , the mucus clogs the airways and traps germs, like bacteria, leading to infections , inflammation , respiratory failure, and other complications. For this reason, minimizing contact with germs is a top concern for people with CF. Protein Disorder And Its Clinical Importance

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Wondering about gathering for Thanksgiving and other winter holidays? Weighing what's safe and what's risky? This fall is different than any other before it. Peripheral artery disease PAD , which occurs when fatty deposits clog arteries outside the heart, is underrecognized and potentially dangerous. The hallmark symptom is leg pain that occurs with exercise, called intermittent claudication. This year, getting a flu shot is more important than ever, because it can not only protect people against the flu, but will also reduce the burden on health care systems. Colon cancer is the second most common cause of cancer deaths, but the death rate has steadily dropped over the past several decades among older adults.

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Thursday, October 17, NIH-funded study suggests sleep clears brain of damaging molecules associated with neurodegeneration. Using mice, researchers showed for the first time that the space between brain cells may increase during sleep, allowing the brain to flush out toxins that build up during waking hours.

These results suggest a new role for sleep in health and disease. For centuries, scientists and philosophers have wondered why people sleep and how it affects the brain. Only recently have scientists shown that sleep is important for storing memories. In this study, Dr.

Nedergaard and her colleagues unexpectedly found that sleep may be also be the period when the brain cleanses itself of toxic molecules. Their results, published in Science, show that during sleep a plumbing system called the glymphatic system may open, letting fluid flow rapidly through the brain.

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Initially the researchers studied the system by injecting dye into the CSF of mice and click here it flow through their brains while simultaneously monitoring electrical brain activity. The dye flowed rapidly when the mice were unconscious, either asleep or anesthetized. In contrast, the dye barely flowed when the same mice were awake. To test this idea, the researchers inserted electrodes into the brain to directly measure the space between brain cells. They found that the space inside the brains increased by 60 percent when the mice were asleep or anesthetized. Certain brain cells, called glia, control flow through the glymphatic system by shrinking or swelling.

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Noradrenaline is an arousing hormone that is also known to control cell volume. Similar to using anesthesia, treating awake mice with drugs that block noradrenaline induced unconsciousness and increased brain fluid flow and the space between cells, further supporting the link between the glymphatic system and consciousness. Previous studies suggest that toxic molecules involved in neurodegenerative disorders accumulate in the space between brain cells.]