Discovery Of The Concentration Of Phosphate - recommend
Subject All. Chemistry Convex lens. Gibbs free energy. Lewis concept of acids. Planetary geology. Social science. Social studies. Sulphur does not form double bonds like oxygen atoms. Discovery Of The Concentration Of PhosphateA basic science discovery by researchers at the Johns Hopkins Bloomberg School of Public Health reveals a fundamental way cells interpret signals from their environment and may eventually pave the way for potential new therapies. The finding involves a signaling pathway in cells, called the Hippo pathway, which normally constrains cell division and regulates the size of organs, and also plays a role in tissue growth and development as well as tumor suppression. The Hippo pathway is so fundamental that it is found in species ranging from humans to flies.
The Bloomberg School researchers clarified the working of this signaling pathway by solving a long-standing mystery of how one of its core components, an enzyme called MST2, can be activated Discovegy multiple signaling inputs. The discovery is reported in a paper on November 20 in the Journal Discovery Of The Concentration Of Phosphate Biological Chemistry. The Hippo pathway normally works as a Phosphaet on cell division that stops organs from growing larger once they have reached the appropriate size.
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Mutations or other abnormalities in the pathway that take the brakes off cell division have been found in many cancers, making elements of the Hippo pathway potential targets for future cancer treatments. Due to its fundamental role of tissue and organ growth, the pathway also is of great interest to researchers who are developing techniques to improve wound healing and stimulate the regeneration of damaged tissue.
The heart of the Hippo pathway begins with the activation of two highly related enzymes, MST1 and MST2, which are almost identical and perform overlapping functions. Normally, proteins that undergo autophosphorylation are activated by a single molecular "event" -- such as binding a particular molecule or interacting with another copy of the same enzyme. In the study, she and her colleagues used test tube and cell culture experiments with human MST2 to show that the myriad upstream activators of this enzyme trigger MST2 autophosphorylation the same way -- simply by increasing the local concentration of these enzymes -- thus reducing the distance between the enzymatic sites on individual enzymes and making it click here for them to phosphorylate one another.
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The researchers believe their discovery is likely to apply not only to MST2 but also its twin MST1 as well as the very similar versions of the enzyme produced in other species. Although this was principally a basic science study, the results should enhance the ability of researchers to manipulate Hippo pathway signaling, both for basic research as well as for potential therapeutic applications for tissue regeneration and anti-cancer therapies. Note: Content may be edited for style and length. Science News. Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling.
ScienceDaily, 20 November Discovery illuminates how cell growth pathway responds to signals: Cell biology finding may lead to better techniques aimed at tissue regeneration and anti-cancer therapies. Retrieved November 22, from www. The discovery is a The work represents an important advance in our understanding of gene regulation and reveals a new layer ScienceDaily shares links with sites in the TrendMD network and earns revenue from third-party advertisers, where indicated. Boy or Girl? Living Well.
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