The Rats With Food Deprivation Video
Tonon AC et al. FeSBE 2019 - Demonstration of sleep deprivation model in Wistar ratsOpinion: The Rats With Food Deprivation
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| The Rats With Food Deprivation | Oct 10, · High-frequency electrical stimulation of the nPO elicited hippocampal network oscillations in the theta range, with a current-dependent increase of peak frequency in both WT and TgFAD rats under urethane anesthesia, in line with previous findings in rats and mice [20, 24,25,26].Consistent with our recent report on TgFAD rats [], stimulus-response analysis showed a reduction in Cited by: 5. 4 days ago · Rats were isotopically equilibrated with daily injections of exogenous [I]T4 while endogenous thyroidal T4 secretion and concentration of iodide were blocked with KCl Following a period of equilibration, either complete or 50% food deprivation was imposed on half the animals. Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. The least common form of narcolepsy, type 1, in which the sufferer experiences brief losses of muscle tone (), is caused by a lack of orexin in the brain due to destruction of the cells that produce it.. There are only 10,–20, orexin-producing neurons in the InterPro: IPR |
The Rats With Food Deprivation The Rats With Food Deprivation - rather valuable
In the clinic selective serotonin reuptake inhibitors SSRIs , like Fluoxetine, remain the primary treatment for major depression. It has been suggested that miR regulates serotonin transporters SERT via raphe nuclei and hippocampal responses to antidepressants. However, the underlying mechanism and regulatory pathways are still obtuse. Here, a chronic unpredicted mild stress CUMS depression model in rats was established, and then raphe nuclei miR and intragastric Fluoxetine injections were administered for a duration of 3 weeks. An open field test and sucrose preference quantification displayed a significant decrease in the CUMS groups when compare to the control groups, however these changes were attenuated by both miR and Fluoxetine treatments. These findings indicate that apoptosis and autophagy related pathways could be involved in the effectiveness of antidepressants, in which miR participates in the regulation of, and is likely to help integrate rapid therapeutic strategies to alleviate depression clinically. These findings indicate that miR participates in the regulation of apoptosis and autophagy and could account for some part of the therapeutic effect of SSRIs. This discovery has the potential to further the understanding of SSRIs and accelerate the development of new treatments for depression. Statistical information from the World Health Organization WHO indicates that by depression will be the greatest source of disability worldwide Albert and Francois, ; Albert and Fiori,Starvation depresses thyroid gland function.
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In addition, the peripheral turnover of thyroxine T4 is reduced, in part due to decreased fecal elimination of T4. The present studies were performed to determine if starvation also affects the deiodinative pathway for T4 degradation. Rats were The Rats With Food Deprivation equilibrated with daily injections of exogenous [I]T4 while endogenous thyroidal T4 secretion and concentration of iodide were blocked with KCl Within 48 h of starvation, the serum T4 concentration of the fully starved rats doubled and remained high throughout.
A marked decrease in fecal excretion of T4 was partially responsible for the increase. In spite of variability in the quantity of urinary I excreted, the dieodinative clearance was consistently reduced.
These effects were readily reversible upon resumption of normal feeding. Similar though Tne severe changes were observed in the half-fed rats. In both fully and partially-starved animals, the decreased dieodinative clearance in the face of increased serum T4 levels indicates a significant impairment of peripheral deiodination by some as yet unknown mechanism. In contrast, normal rats equilibrated with doses of T4 sufficient to increase serum T4 levels exhibit increased urinary clearance of iodide derived from T4. Thus the see more serum T4 levels are a consequence of impairment of the deiodinative pathway by starvation as well as decreased fecal T4 excretion.
Background
Clearly, voluntary alterations in food consumption must be controlled for differences between groups during experimental studies of T4 utilization. The effect of food deprivation of the peripheral metabolism of thyroxine in rats.
N2 - Starvation depresses thyroid gland function. AB - Starvation depresses thyroid gland function.
Original Research ARTICLE
Overview Fingerprint. Abstract Starvation depresses thyroid gland function. Gov't, Non-P. Research Support, U. Gov't, P.
Access Endocrinology96 6 In: EndocrinologyVol. In: Endocrinology.]
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