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The Excitement Phase Is Over And I - sorry

Preclinical studies have shown BP to be a potent inhibitor against the Bcl-2 target, and the Company believes that its benign safety profile should enable BP combination therapy with approved agents. The treatment cycle consists of two doses per week over four weeks, resulting in eight doses administered over twenty-eight days. The primary objectives of the study include safety and tolerability of escalating doses of BP, recommended Phase 2 dose of BP, pharmacokinetics of BP and BP activity on Bcl-2 expression. Secondary endpoints include several efficacy measurements of tumor response. As a result, we believe BP may provide a much-needed alternative for patients with malignancies that relapsed or are refractory to venetoclax. Ian W. Flynn, M. Flynn is the director of lymphoma research at the Sarah Cannon Research Institute. Anderson Cancer Center. This is followed by BP, targeting the Bcl-2 protein, where it is being evaluated in lymphoma clinical studies.

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Pfizer announced positive early results from its coronavirus vaccine trial, cementing the lead in a frenzied global race that has unfolded at record-breaking speed. The drug maker Pfizer announced on Monday that an early analysis of its coronavirus vaccine trial suggested the vaccine was robustly effective in preventing Covid , a promising development as the world has waited anxiously for any positive news about a pandemic that has killed more than 1. Pfizer, which developed the vaccine with the German drugmaker BioNTech, released only sparse details from its clinical trial, based on the first formal review of the data by an outside panel of experts. The company said that the analysis found that the vaccine was more than 90 percent effective in preventing the disease among trial volunteers who had no evidence of prior coronavirus infection. If the results hold up, that level of protection would put it on par with highly effective childhood vaccines for diseases such as measles. No serious safety concerns have been observed, the company said. Pfizer plans to ask the Food and Drug Administration for emergency authorization of the two-dose vaccine later this month, after it has collected the recommended two months of safety data. By the end of the year it will have manufactured enough doses to immunize 15 million to 20 million people, company executives have said. The news comes just days after Joseph R. The Excitement Phase Is Over And I

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