Effects Of Nicotine On Children And Non Video
2-Minute Neuroscience: Nicotine Effects Of Nicotine On Children And Non.Background: Perinatal asphyxia triggers a large cascade of mechanisms leading to brain damage.
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Release of glutamate and increased oxidative stress play substantial roles. Non-protein-bound iron NPBIwhich contributes to the production of free radical species through the Fenton reaction, increases in hypoxic-ischemic brain damage.
Results from in vitro and adult animal studies show that nicotine can decrease extracellular levels of NPBI and glutamate. Nicotine's effects have further been shown to be dose-dependent, with lower doses showing neuroprotective, and higher doses showing neurotoxic effects.
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Objectives: We wished to assess nicotine's effect on levels of NPBI and glutamate in an animal model of neonatal hypoxic-ischemic brain damage. Glutamate in striatum and NPBI in cortex were analyzed in microdialysate. Conclusion: Our findings support the hypothesis that nicotine can decrease extracellular levels of glutamate and NPBI in a neonatal model of hypoxic-ischemic brain damage. This suggests possible Nkcotine effects of a low dose of nicotine in neonates, as it has already been shown in adult models.
Abstract Background: Perinatal asphyxia triggers a large cascade of mechanisms leading to brain damage. Publication types Research Support, Non-U.]
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