Effects Of Nicotine On Children And Non Video
2-Minute Neuroscience: Nicotine Effects Of Nicotine On Children And Non.Background: Perinatal asphyxia triggers a large cascade of mechanisms leading to brain damage.
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Release of glutamate and increased oxidative stress play substantial roles. Non-protein-bound iron NPBIwhich contributes to the production of free radical species through the Fenton reaction, increases in hypoxic-ischemic brain damage.
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Results from in vitro and adult animal studies show that nicotine can decrease extracellular levels of NPBI and glutamate. Nicotine's effects have further been shown to be dose-dependent, with lower doses showing neuroprotective, and higher doses showing neurotoxic effects.
Publication types
Objectives: We wished to assess nicotine's effect on levels of NPBI and glutamate in an animal model of neonatal hypoxic-ischemic brain damage. Glutamate in striatum and NPBI in cortex were analyzed in microdialysate. Conclusion: Our findings support the hypothesis that nicotine can decrease extracellular levels of glutamate and NPBI in a neonatal model of hypoxic-ischemic brain damage. This suggests possible Nkcotine effects of a low dose of nicotine in neonates, as it has already been shown in adult models.
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Abstract Background: Perinatal asphyxia triggers a large cascade of mechanisms leading to brain damage. Publication types Research Support, Non-U.]
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