Proteins Are Colonic Epithelial Receptors For C - amazonia.fiocruz.br

Proteins Are Colonic Epithelial Receptors For C Video

G protein coupled receptor mediated signaling

Proteins Are Colonic Epithelial Receptors For C - realize, told

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Recently, several homologues of the catalytic component of the phagocyte oxidase, gp91 phoxwere identified in various tissues.

Discuss the Beneficial Effects of Activated Protein C in the Treatment of Severe Sepsis

Here we describe two proteins, p41 and p51, with significant homology to two cytosolic components of the phagocytic oxidase, p47 phox and p67 phox. Like p47 phoxp41 contains an amino-terminal Phox homology domain, two SH3 domains, and a conserved carboxyl-terminal, proline-rich motif.

The highest levels of p41 Cklonic are detected in the colon and in other gastrointestinal tissues that express Nox1, the predominant gp91 phox homologue in these tissues. In contrast, the p51 transcript showed a more widespread expression pattern, suggesting that it may support other tissue-specific oxidases. Mouse colon in situ hybridization detected both transcripts in the epithelial cells of colon crypts. Heterologous co-expression of p41 and p51 significantly enhances the superoxide-generating activity of Nox1-expressing cells; thus, p41 and p51 appear to be novel regulators of Nox1.

These proteins also support the Redeptors of gp91 phoxalbeit at much lower levels than the cytosolic phox counterparts. Our results suggest colon epithelial cells contain a multi-component NAD P H oxidase with a molecular architecture similar to the phagocytic oxidase. You'll be in good company. Journal of Lipid Research. View this article with LENS.

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