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Pfizer announced positive early results from its coronavirus vaccine trial, cementing the lead in a frenzied global race that has unfolded at record-breaking speed. The drug maker Pfizer announced on Monday that an early analysis of its coronavirus vaccine trial suggested the vaccine was robustly effective in preventing Covid , a promising development as the world has waited anxiously for any positive news about a pandemic that has killed more than 1. Pfizer, which developed the vaccine with the German drugmaker BioNTech, released only sparse details from its clinical trial, based on the first formal review of the data by an outside panel of experts. The company said that the analysis found that the vaccine was more than 90 percent effective in preventing the disease among trial volunteers who had no evidence of prior coronavirus infection. If the results hold up, that level of protection would put it on par with highly effective childhood vaccines for diseases such as measles. No serious safety concerns have been observed, the company said. Pfizer plans to ask the Food and Drug Administration for emergency authorization of the two-dose vaccine later this month, after it has collected the recommended two months of safety data. By the end of the year it will have manufactured enough doses to immunize 15 million to 20 million people, company executives have said. Dna Knowledge And Its Effects On The

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Find more information continue reading the Altmetric Attention Score and how the score is calculated. The biophysical properties of a designed bioreducible oligourea foldamer, which shows excellent transfection activities in its dimeric form are presented. Binding isotherms of the monomer as well as of the dimer to both DNA and lipid membranes were determined by indole fluorescence. Knowlexge the monomer with the dimer allows both a precise biophysical characterization of the role of dimerization and characterization of how the covalent linkage between two monomers affects the transfection activity.

The results indicate that dimerization results in hTe changes in the thermodynamics of different steps of the transfection Dna Knowledge And Its Effects On The, which extend well beyond simple steric effects within the dimer. A model emerges where the imidazole-containing polymers compact DNA at neutral pH, but they liberate the polyurea from the DNA complex at low pH, thus being able to rupture acidified endosomes. Indeed, the dimerization inverts the pH dependence of the binding affinities toward the requirements suggested by this model for efficient transfection.

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