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An Introduction to Pharmacogenomics. An Introduction to Pharmacogenomics Multiple Choice Identify the choice that best completes the statement or answers the question. Genetic polymorp Poor metabolizers, who lack a working enzyme 2.
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Intermediate metabolizers, who have one working, wild-type allele and one mu-tant allele 3. Extensive metabolizers, with two normally functioning alleles 4.
A need to monitor drugs metabolized by 2D6 for toxicity 2. Increased dosages needed of drugs metabolized by 2D6, such as the selective ser-otonin reuptake inhibitors 3. Decreased conversion of codeine to morphine by CYP 2D6 4.
Rifampin is a nonspecific CYP inducer that may: 1. Lead to toxic levels of rifampin and must be monitored closely 2. Cause toxic levels of drugs, such as oral contraceptives, when coadministered 3.
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Induce the metabolism of drugs, such as oral contraceptives, leading to therapeu-tic failure 4. Inhibition of P-glycoprotein by a drug such as quinidine may lead to: 1. Decreased therapeutic levels of quinidine 2. Increased therapeutic levels of quinidine 3. Decreased levels of a coadministered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination 4.]
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