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The Myelin Sheath And Its Effects On Video

Effects of axon diameter and myelination - Nervous system physiology - NCLEX-RN - Khan Academy The Myelin Sheath And Its Effects On

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Christian Haass, Ph. BACE1 was found to process neuregulin into its active form and BACE1-deficient mice displayed defects in axon myelination and bundling. Potential side effects of drugs targeting BACE1 should be considered. Abstract Full Text subscription or payment may be required Abstract Full Text subscription or payment may be required. All rights reserved. This site complies with the HONcode standard for trustworthy health. Second study suggests Alzheimer disease-related peptides may share some similarities with prions.

The Myelin Sheath And Its Effects On - quite apologise

A Look at Myelin and Myelin-Related Disorders Myelin is the protective sheath around axons in the nervous system, and is often referred to as 'white matter. The myelin sheath contains a variety of fatty substances lipids , and contains at least ten distinct chemicals 2. From what is known, axons are not fully myelinated. English Abstract Multiple sclerosis MS is a chronic inflammatory, neurodegenerative disease that affects more than 40, individuals in Egypt alone and 2. MS is also categorized as an autoimmune disease in which the immune system instigates an immune response upon encountering the specific myelin antigen and therefore initiating a constant degradation of the myelin sheath. The frequent loss of the myelin leads to irreversible. What Everyone Should Know About Multiple Sclerosis Multiple sclerosis is considered a nervous system disease that affects the brain and spinal cord. The disease remains a mystery to this day since there are no known specific causes. It can be seen that multiple sclerosis is more prevalent in women than in men between the ages of Bethesda

A demyelinating disease is any disease of the nervous system in which the myelin sheath of neurons is damaged. In turn, the reduction in conduction ability causes deficiency in sensation, movement, cognition, or other functions depending on which nerves are involved.

Second study suggests Alzheimer disease-related peptides may share some similarities with prions

Demyelinating diseases can be caused by geneticsinfectious agents, autoimmune Effefts, and other unknown factors. Proposed causes for demyelination include genetics and environmental factors such as being triggered by a viral infection or chemical exposure. Organophosphate poisoning by commercial insecticides such as sheep dipweed killersand flea treatment preparations for pets, can also result in nerve demyelination. Demyelinating diseases are traditionally classified in two kinds: demyelinating myelinoclastic diseases and demyelinating leukodystrophic diseases. In see more first group, a normal and healthy myelin is destroyed by a toxic, chemical, or autoimmune substance. In the second group, myelin is abnormal and degenerates.

A Look at Myelin and Myelin-Related Disorders Essay

In the most well known example of demyelinating disease, multiple sclerosisevidence has shown that the body's own immune system is at least partially responsible. Acquired immune system cells called T-cells are known to be present at the site of lesions. Other immune-system cells called macrophages and possibly mast cells also contribute to the damage. Symptoms and signs that present in demyelinating diseases are different for each condition.

These symptoms and signs can present in a person with a demyelinating disease: [9]. The role of prolonged cortical myelination in human evolution has been implicated as a contributing factor in some cases of demyelinating disease. Unlike other primates, humans exhibit a unique pattern of postpubertal myelination, which may contribute to the development of psychiatric disorders and neurodegenerative diseases that present in early adulthood and beyond.

The extended period of cortical myelination in humans may allow greater opportunity for disruption in myelination, resulting in the onset of demyelinating disease. Evolutionary considerations for the role of prolonged cortical myelination as a risk factor for demyelinating disease are particularly pertinent given that genetics and autoimmune deficiency hypotheses fail to explain many cases of demyelinating disease. As has been argued, diseases such as multiple sclerosis cannot be accounted for by autoimmune deficiency alone, but strongly imply The Myelin Sheath And Its Effects On influence of flawed developmental processes in disease pathogenesis.

Demyelinating diseases can be divided in those affecting the central nervous system CNS and those affecting the peripheral nervous system PNS. They can also be classified by the presence or absence of inflammation. Finally, a division may be made based on the underlying cause of demyelination: the disease process can be demyelinating myelinoclasticwherein myelin is destroyed; or dysmyelinating leukodystrophicwherein myelin is abnormal and degenerative.

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The demyelinating disorders of the central nervous system include:. The myelinoclastic disorders are typically associated with symptoms such as optic neuritis and transverse myelitisbecause the demyelinating inflammation can affect the optic nerve or spinal cord. Many are idiopathic.

Both myelinoclastic and leukodystrophic modes of disease may result in lesional demyelinations of the central nervous system. The demyelinating diseases of the peripheral nervous system include:.]