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Opinion: Changes Associated With Left Ventricular Hypertrophy With

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Lowering of blood pressure to less than systolic and 80 diastolic mm of Hg irrespective of cardiovascular risk is recommended. While intensive blood pressure control is commonly achievable with rational pharmacotherapy, the magnitude of here ventricular hypertrophy regression is an independent factor in improvement in cardiovascular health.

The regression of left ventricular hypertrophy has been adjudged as a clinically useful surrogate marker that reflects the efficacy of hypertension treatment. Left ventricular mass index was determined using echocardiography at baseline and after 24 weeks of therapy. The left ventricle of the heart shows a time-dependent, compensatory response to blood pressure BP resulting in adaptive change in myocardial thickness. In patients of primary hypertension, increase in left ventricular mass occurs in response to chronic pressure overload that tends to stabilize the equilibrium between the left ventricular wall stress and the increased BP. An exaggerated increase Changes Associated With Left Ventricular Hypertrophy With myocardial thickness in due course of time leads to concentric left ventricular hypertrophy LVH 1. A definite association has been established, not only between hypertension and LVH, but also between LVH and cardiovascular events, both of which, cumulatively and independently, increase the risk of cardiovascular mortality and morbidity 4.

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LVH is independently associated with four-fold greater risk of cardiovascular events Statistically, a mathematical relationship exists between left ventricular mass in grams and the rate of cardiovascular events 4. However, pharmaco-therapy directed at reducing elevated BP reduces complications associated with hypertension. It has also been observed that with prolonged control of BP there is regression of LVH with significant decrease of unfavourable clinical outcomes. There are plenty of studies that show the Changes Associated With Left Ventricular Hypertrophy With of the risk of adverse cardiovascular events with regression of LVH In patients of hypertension with diabetes, it has been shown that greater lowering of BP leads to greater reduction in the risk of LVH Most patients require a second drug in the long run for optimum control of BP. An observational prospective cohort study was conducted to compare the regression of LVH in patients with essential hypertension attending the medicine out-patient department at AIIMS, Bhopal.

Informed consent was obtained from all individual participants included in the study. The sample size was calculated using effect size.

INTRODUCTION

Effect size is a standard measure of the difference between two or more groups independent of the unit of the outcome variable. For simplicity, effect size is categorised into three levels-small, medium and large. Keeping alpha probability of 0.

Based on clinical judgement and practical feasibility, we decided to use a medium effect size Hypertro;hy our study. The total sample size for the specified effect size was calculated as for four independent groups. Thus, 45 patients were required per group for the study. All participants in the study were patients of uncontrolled essential hypertension.

The inclusion criteria for the study were: 1. Age between 35 and 85 years old; 2.]