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Case 1: Stage IV Ovarian Cancer With Multiple Metastatic Sites

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November 18, A new paper in JNCI: Journal of the National Cancer Institute , published by Oxford University Press, indicates that receiving assisted reproductive technology does not increase the risk women have for developing ovarian cancer. Previous research indicated that women who use assisted reproductive technology in order to have a successful pregnancy could potentially be at risk for ovarian cancer and non-malignant borderline ovarian tumors due to excess stimulation of the ovaries. Since the introduction of assisted reproductive technology —including in vitro fertilization, intracytoplasmic sperm injection and cryopreservation of embryos —four decades ago, some researchers have raised concerns that such technology might increase the risk of ovarian tumors. Researchers have proposed that this could potentially be due to large increases of sex hormone levels and multiple punctures disrupting ovarian tissue. Because of the worldwide increase in the use of fertility treatments and the poor prognosis of ovarian cancer, it is important to examine the association between fertility treatments and long-term risk of ovarian tumors. Several epidemiological studies have investigated the association between such treatments and risk of ovarian tumors, with inconsistent results. In , two meta-analyses were published showing that women who received fertility treatments were more likely to develop ovarian cancer compared with the general population. But it remained unclear if fertility treatments caused women to develop ovarian cancer or if the association could be due to other factors, such as infertility itself. Ovarian Cancer Research Paper

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