Charcot Marie Tooth Disorder - amazonia.fiocruz.br

Charcot Marie Tooth Disorder - what

The most common inheritance pattern is autosomal dominant, though there also are X-linked and autosomal recessive subtypes. In addition to a variety of inheritance patterns, there are a myriad of genes associated with CMT, reflecting the heterogeneity of this disorder. In this review, we highlight the clinical background, molecular understanding, and therapeutic investigations of these CMT subtypes, while also discussing therapeutic research pertinent to the remaining less common CMT subtypes. Keywords: Charcot-Marie-Tooth; gene therapy; hereditary neuropathy; molecular therapy. Publication types Review.

Charcot Marie Tooth Disorder - opinion you

These findings highlight how important it is for these patients to do their best to exercise and maintain their strength; unfortunately, the pandemic means that many patients may have to establish new routines. Charcot-Marie-Tooth disease is a hereditary disorder of the peripheral nervous system. It is most characterized by a progressive loss of touch sensation and muscle tissue in several different parts of the body. The cause of this disease is usually linked to a genetic mutation, but the mutation involved varies depending on the variant of Charcot-Marie-Tooth disease. There are multiple types of Charcot-Marie-Tooth disease, with all types aside from type 2 having a demyelination effect. Type 2 causes damage to the neuronal axon instead. Symptoms include foot drop, muscle wasting typically in the arms, legs, and hands , painful muscle spasms, loss of sensation in the limbs, scoliosis, trouble speaking, chewing, and swallowing, and tremors. Charcot Marie Tooth Disorder

Charles Sandersassociate dean for research and professor of biochemistry, will continue to lead research and pursue a therapeutic treatment for Charcot-Marie-Tooth disease, a disease that affects one in 2, people. Bruce Carter Vanderbilt University Chuck Sanders Vanderbilt University Charles Sandersassociate dean for research and professor of biochemistry, will continue to lead research and pursue a therapeutic treatment for Charcot-Marie-Tooth disease, a disease that affects one in 2, people.

Keep Reading. Vanderbilt biochemists reveal the cause of Charcot-Marie-Tooth disease—too much of a good thing.]